Ir基因在半抗原特异性迟发型超敏反应的诱导和激发中控制载体效应。
Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses.
作者信息
Weinberger J Z, Benacerraf B, Dorf M E
出版信息
J Exp Med. 1979 Nov 1;150(5):1255-9. doi: 10.1084/jem.150.5.1255.
Abstract
The genetic requirements of carrier recognition were examined in the priming and elicitation of hapten specific, T-cell mediated, delayed-type hypersensitivity (DTH) responses. It was shown that nitrophenyl acetyl-poly-(L-glu56-L-lys35-L-phe9) (NP-GLO) could prime for NP responses only in strains of mice which are Ir gene responders to GLO. In contrast to this requirement, NO-GLO could elicit an NP-specific response in NP-bovine gamma globulin primed mice, even in GLO nonresponder strains. Furthermore, the nonimmunogenic molecule, NP-GL, could elicit an NP-specific DTH response in animals primed with NP on an immunogenic carrier.
摘要
在半抗原特异性、T细胞介导的迟发型超敏反应（DTH）的启动和激发过程中，研究了载体识别的遗传需求。结果表明，硝基苯基乙酰基-聚-（L-谷氨酸56-L-赖氨酸35-L-苯丙氨酸9）（NP-GLO）仅能在对GLO为Ir基因应答者的小鼠品系中引发NP反应。与这一需求相反，NO-GLO能够在NP-牛γ球蛋白致敏的小鼠中引发NP特异性反应，即使在GLO无应答品系中也是如此。此外，非免疫原性分子NP-GL能够在免疫原性载体上用NP致敏的动物中引发NP特异性DTH反应。
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