H-2基因复合体限制小鼠迟发型超敏反应的转移。
H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice.
作者信息
Miller J F, Vadas M A, Whitelaw A, Gamble J
出版信息
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5095-8. doi: 10.1073/pnas.72.12.5095.
Abstract
Sensitized lymphocytes can transfer a state of delayed-type hypersensitivity to soluble protein antigens to naive mice only if donor and recipient share the I-A region of the H-2 gene complex. Identity at the K or D region is not essential. The restriction is unlikely to result from ineffective homing of the injected cells or from their early destruction. It is thought to reflect a requirement for an Ir-gene controlled mechanism which governs effective interaction between sensitized T lymphocytes and antigen presented on the surface of macrophages.
摘要
致敏淋巴细胞只有在供体和受体共享H-2基因复合体的I-A区域时，才能将迟发型超敏反应状态转移给对可溶性蛋白质抗原本不敏感的小鼠。K或D区域的一致性并非必需。这种限制不太可能是由于注射细胞归巢无效或早期被破坏所致。人们认为这反映了一种对Ir基因控制机制的需求，该机制支配着致敏T淋巴细胞与巨噬细胞表面呈递的抗原之间的有效相互作用。
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