Flügel A, Bradl M
Max-Planck-Institute of Neurobiology, Munich, Germany.
Glia. 2001 Nov;36(2):125-36. doi: 10.1002/glia.1102.
Cells of the central nervous system (CNS) and immune system communicate regularly. There is a constant surveillance of the intact, healthy CNS by activated T-cells, and massive infiltration of the CNS by immune cells under pathological conditions such as neurodegeneration or neuroinflammation. Labeling CNS-infiltrating T-cells is an essential tool to identify the signals and mechanisms, which mediate the interaction between immune cells and cells of the CNS. In this article, we will present an overview describing currently used cellular markers and demonstrate how these markers have contributed to our current knowledge of CNS inflammation and immune surveillance.
中枢神经系统（CNS）的细胞与免疫系统会定期进行交流。活化的T细胞会持续监测完整、健康的中枢神经系统，在诸如神经退行性变或神经炎症等病理条件下，免疫细胞会大量浸润中枢神经系统。标记浸润中枢神经系统的T细胞是识别介导免疫细胞与中枢神经系统细胞间相互作用的信号和机制的重要工具。在本文中，我们将概述目前使用的细胞标志物，并展示这些标志物如何增进了我们对中枢神经系统炎症和免疫监测的现有认识。
