Aloisi F
Neurophysiology Unit, Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanità, Roma, Italy.
Glia. 2001 Nov;36(2):165-79. doi: 10.1002/glia.1106.
During the past decade, mechanisms involved in the immune surveillance of the central nervous system (CNS) have moved to the forefront of neuropathological research mainly because of the recognition that most neurological disorders involve activation and, possibly, dysregulation of microglia, the intrinsic macrophages of the CNS. Increasing evidence indicates that, in addition to their well-established phagocytic function, microglia may also participate in the regulation of non specific inflammation as well as adaptive immune responses. This article focuses on the signals regulating microglia innate immune functions, the role of microglia in antigen presentation, and their possible involvement in the development of CNS immunopathology.
在过去十年中，中枢神经系统（CNS）免疫监视所涉及的机制已成为神经病理学研究的前沿领域，这主要是因为人们认识到大多数神经系统疾病都涉及小胶质细胞（CNS的固有巨噬细胞）的激活以及可能的失调。越来越多的证据表明，除了其已确立的吞噬功能外，小胶质细胞还可能参与非特异性炎症以及适应性免疫反应的调节。本文重点关注调节小胶质细胞固有免疫功能的信号、小胶质细胞在抗原呈递中的作用以及它们可能参与CNS免疫病理学发展的情况。
