Nettesheim P, Creasia D A, Mitchell T J
J Natl Cancer Inst. 1975 Jul;55(1):159-69. doi: 10.1093/jnci/55.1.159.
The carcinogenic and cocarcinogenic activity of synthetic smog, ferric oxide (Fe2O3) dust, and a mixture of the two air contaminants was determined in a long-term inhalation study with Syrian hamsters. Inhaled Fe2O3 particles definitely enhanced diethylnitrosamine tumorigenicity in the peripheral lung. Synthetic smog did not. When tested at a concentration of 40 ppm methane equivalents or 40 mg/m3, respectively, neither air pollutant by itself appeared carcinogenic. Fe2O3 caused pulmonary fibrosis and synthetic smog caused alveolar bronchiolization in many of the exposed animals.
在一项针对叙利亚仓鼠的长期吸入研究中，测定了合成烟雾、三氧化二铁（Fe2O3）粉尘以及这两种空气污染物混合物的致癌和促癌活性。吸入的Fe2O3颗粒确实增强了二乙基亚硝胺在外周肺中的致癌性。合成烟雾则没有。当分别以40 ppm甲烷当量或40 mg/m3的浓度进行测试时，这两种空气污染物单独出现时均未表现出致癌性。Fe2O3导致许多暴露动物出现肺纤维化，而合成烟雾导致许多暴露动物出现肺泡细支气管化。
