Di Stadio Arianna, Gambacorta Valeria, de Crescenzo Stefano, Sidoni Angelo, Cristi Maria Cristina, Di Giovanni Alfredo, Maranzano Massimo, Ricci Giampietro
Department of Otolaryngology, University of Perugia, I-65121 Perugia, Italy.
Department of Anatomic Pathology, University of Perugia, I-65121 Perugia, Italy.
Mol Clin Oncol. 2020 May;12(5):451-455. doi: 10.3892/mco.2020.2007. Epub 2020 Feb 26.
A correlation between inflammation and cancer has been identified in the case of nasal cancer, however a specific connection between nasal inflammation and extramedullary nasal plasmacytoma (ENP), to the best of our knowledge, has not yet been determined. The present case report describes a patient affected by ENP, in who the tumor arose in the same area, from which a nasal polyp was previously surgically removed, five months after the polyp excision. The patient underwent surgical endoscopic tumor asportation without being treated with radio-chemotherapy. ENP was totally removed via surgery and no signs of recurrence were identified by endoscopy or magnetic resonance imaging during the last check-up 1 year after tumor asportation. It was hypothesized that in this elderly patient, who was exposed to viral infections and pollution for several years, ENP may be correlated to the inflammatory process that occurred after surgery, and this likely contributed to a neoplastic mutation in B-cells.
在鼻咽癌病例中已发现炎症与癌症之间存在关联，然而据我们所知，鼻炎症与鼻外髓质浆细胞瘤（ENP）之间的具体联系尚未确定。本病例报告描述了一名患有ENP的患者，该肿瘤在息肉切除五个月后，出现在先前通过手术切除鼻息肉的同一区域。该患者接受了手术内镜肿瘤切除，未接受放化疗。通过手术ENP被完全切除，在肿瘤切除后1年的最后一次检查中，内镜检查或磁共振成像未发现复发迹象。据推测，在这位多年暴露于病毒感染和污染的老年患者中，ENP可能与手术后发生的炎症过程相关，这可能促成了B细胞的肿瘤性突变。
