沙眼衣原体感染男性的尿道细胞因子和免疫反应
Urethral cytokine and immune responses in Chlamydia trachomatis-infected males.
作者信息
Pate M S, Hedges S R, Sibley D A, Russell M W, Hook E W, Mestecky J
机构信息
Department of Microbiology, The University of Alabama at Birmingham, and Jefferson County Department of Health, Birmingham, Alabama 35294, USA.
出版信息
Infect Immun. 2001 Nov;69(11):7178-81. doi: 10.1128/IAI.69.11.7178-7181.2001.
Abstract
Penile urethral swabs collected from PCR-confirmed Chlamydia trachomatis-infected, C. trachomatis-uninfected, and non-C. trachomatis-infected, nongonococcal urethritis-infected males were analyzed for cytokine, total immunoglobulin (Ig), and specific antibody levels by enzyme-linked immunosorbent assay. Differential cellular components of the swab transport medium were also enumerated for the same groups. Although low, the levels of C. trachomatis-specific IgA and IgG antibodies and interleukin 8 cytokine were significantly higher in C. trachomatis-infected individuals. There were no significant differences in the levels of seven additional cytokines evaluated.
摘要
从经聚合酶链反应（PCR）确诊感染沙眼衣原体、未感染沙眼衣原体以及未感染沙眼衣原体但感染非淋菌性尿道炎的男性中采集阴茎尿道拭子，通过酶联免疫吸附测定法分析细胞因子、总免疫球蛋白（Ig）和特异性抗体水平。还对相同组别的拭子转运培养基中的不同细胞成分进行了计数。虽然水平较低，但沙眼衣原体感染个体中沙眼衣原体特异性IgA和IgG抗体以及白细胞介素8细胞因子的水平显著更高。所评估的另外七种细胞因子水平没有显著差异。
相似文献
1
Urethral cytokine and immune responses in Chlamydia trachomatis-infected males.
Infect Immun. 2001 Nov;69(11):7178-81. doi: 10.1128/IAI.69.11.7178-7181.2001.
2
Chlamydia trachomatis antibodies in serum and ejaculate of male patients without acute urethritis.
Ann Urol (Paris). 1996;30(3):139-46.
3
[Specific IgM and IgA antibodies in Chlamydia trachomatis infections in adults].
Ann Biol Clin (Paris). 1988;46(8):688-91.
4
Serum specific IgA antibody to Chlamydia trachomatis in patients with chlamydial infections detected by ELISA and an immunofluorescence test.
J Clin Pathol. 1984 Jun;37(6):686-91. doi: 10.1136/jcp.37.6.686.
5
Tear anti-Chlamydia antibodies in males with chlamydial urethritis.
Ophthalmic Res. 1993;25(1):23-9. doi: 10.1159/000267217.
6
Chlamydia trachomatis and male infertility: chlamydia-IgA antibodies in seminal plasma are C. trachomatis specific and associated with an inflammatory response.
J Eur Acad Dermatol Venereol. 1999 Mar;12(2):143-52.
7
Chlamydia keratoconjunctivitis determination of Chlamydia trachomatis specific secretory immunoglobulin A in tears by enzyme immunoassay.
Graefes Arch Clin Exp Ophthalmol. 1992;230(5):411-5. doi: 10.1007/BF00175924.
8
Diagnosing Chlamydia Trachomatis Urinary Tract Infections--Preliminary Report.
Adv Clin Exp Med. 2015 May-Jun;24(3):441-5. doi: 10.17219/acem/43719.
9
Class specific immunoglobulin response to individual polypeptides of Chlamydia trachomatis, elementary bodies, and reticulate bodies in patients with chlamydial infection.
J Clin Pathol. 1986 Dec;39(12):1313-6. doi: 10.1136/jcp.39.12.1313.
10
[Study of Chlamydia trachomatis in non gonococcal urethritis. Detection of IgA antibody in sera by ELISA technique].
Nihon Hinyokika Gakkai Zasshi. 1988 Oct;79(10):1605-12. doi: 10.5980/jpnjurol1928.79.10_1605.
引用本文的文献
1
The possible pathogenic mechanisms of microorganisms in infertility: a narrative review.
Arch Microbiol. 2025 Jan 8;207(2):27. doi: 10.1007/s00203-024-04231-w.
2
Lower Urinary Tract Inflammation and Infection: Key Microbiological and Immunological Aspects.
J Clin Med. 2024 Jan 5;13(2):315. doi: 10.3390/jcm13020315.
3
Changes in Inflammatory Cytokine Levels in Rectal Mucosa Associated With Neisseria gonorrheae and/or Chlamydia trachomatis Infection and Treatment Among Men Who Have Sex With Men in Lima, Peru.
J Infect Dis. 2024 Mar 14;229(3):845-854. doi: 10.1093/infdis/jiad349.
4
Serum and Urethral Antibody Response in Mycoplasma genitalium -Infected Men.
Sex Transm Dis. 2023 Oct 1;50(10):e26-e29. doi: 10.1097/OLQ.0000000000001845. Epub 2023 Jul 2.
5
HIV, asymptomatic STI, and the rectal mucosal immune environment among young men who have sex with men.
PLoS Pathog. 2023 May 30;19(5):e1011219. doi: 10.1371/journal.ppat.1011219. eCollection 2023 May.
6
Profile of sexually transmitted infections causing urethritis and a related inflammatory reaction in urine among heterosexual males: A flow-cytometry study.
PLoS One. 2020 Dec 2;15(12):e0242227. doi: 10.1371/journal.pone.0242227. eCollection 2020.
7
Male infertility: a public health issue caused by sexually transmitted pathogens.
Nat Rev Urol. 2014 Dec;11(12):672-87. doi: 10.1038/nrurol.2014.285. Epub 2014 Oct 21.
8
Evaluation of intra- and extra-epithelial secretory IgA in chlamydial infections.
Immunology. 2014 Dec;143(4):520-30. doi: 10.1111/imm.12317.
9
Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens.
Immunol Cell Biol. 2014 May-Jun;92(5):417-26. doi: 10.1038/icb.2013.110. Epub 2014 Jan 21.
10
Effect of HIV and chlamydia infection on rectal inflammation and cytokine concentrations in men who have sex with men.
Clin Vaccine Immunol. 2013 Oct;20(10):1517-23. doi: 10.1128/CVI.00763-12. Epub 2013 Jul 31.
本文引用的文献
1
Detection of Antibodies to Chlamydia trachomatis With Peptide-Based Species-Specific Enzyme Immunoassay.
Infect Dis Obstet Gynecol. 1997;5(5):349-54. doi: 10.1155/S1064744997000616.
2
Clinical consequences of immune responses to Chlamydia in men.
Infect Dis Obstet Gynecol. 1996;4(3):136-42. doi: 10.1155/S1064744996000300.
3
Resolution of secondary Chlamydia trachomatis genital tract infection in immune mice with depletion of both CD4+ and CD8+ T cells.
Infect Immun. 2001 Apr;69(4):2643-9. doi: 10.1128/IAI.69.4.2643-2649.2001.
4
Chlamydia trachomatis infection of epithelial cells induces the activation of caspase-1 and release of mature IL-18.
J Immunol. 2000 Aug 1;165(3):1463-9. doi: 10.4049/jimmunol.165.3.1463.
5
Interleukin 18: a pleiotropic participant in chronic inflammation.
Immunol Today. 2000 Jul;21(7):312-5. doi: 10.1016/s0167-5699(00)01648-0.
6
Summary of Notifiable Diseases, United States, 1998.
MMWR Morb Mortal Wkly Rep. 1999 Dec 31;47(53):ii-92.
7
Global prevalence and incidence estimates of selected curable STDs.
Sex Transm Infect. 1998 Jun;74 Suppl 1:S12-6.
8
Cytokine and antibody responses in women infected with Neisseria gonorrhoeae: effects of concomitant infections.
J Infect Dis. 1998 Sep;178(3):742-51. doi: 10.1086/515372.
9
Route of infection that induces a high intensity of gamma interferon-secreting T cells in the genital tract produces optimal protection against Chlamydia trachomatis infection in mice.
Infect Immun. 1998 Sep;66(9):4030-5. doi: 10.1128/IAI.66.9.4030-4035.1998.
10
Cytokine repertoire of epithelial cells lining the human urinary tract.
J Urol. 1998 Jun;159(6):2185-92. doi: 10.1016/S0022-5347(01)63303-2.
Zotero 插件