Do Amaral V F, Ferriani R A, Dos Reis R M, De Sala M M, De Moura M D
Department of Obstetrics and Gynecology, Faculty of Medicine of Ribeirao Preto, University of São Paulo, 14049-900 Ribeirao Preto, São Paulo, Brazil.
J Assist Reprod Genet. 2001 Aug;18(8):413-6. doi: 10.1023/a:1016678519490.
Intrauterine insemination (IUI) is a method for the treatment of marital infertility involving the intrauterine or fallopian deposition of washed spermatozoa, depending on the amount of inseminated semen. In view of the divergent opinions about the inseminated volume, the objective of this study was to compare the two techniques (3.0 mL or 0.5 mL) in two groups of patients.
We performed 164 cycles of ovulation induction followed by IUI. The patients were divided into two groups according to the technique used. Group low volume--50 cycles and 0.5 mL of inseminated semen; Group high volume--114 cycles and 3.0 mL of inseminated semen. The cycle was monitored on the basis of endometrial thickness and follicular development measured by transvaginal ultrasound. Human chorionic gonadotrophin (hCG) was administered in the presence of a follicle measuring 18 mm in mean diameter. The procedure was performed after sperm washing using a discontinuous PureSperm gradient, 40 h later.
We obtained a similar clinical pregnancy rate for the two groups (14.0% for Group low volume and 15.7% for Group high volume). There was one abortion in each group. We detected no interference by any etiology of infertility or by the total motile recovered sperm with pregnancy rate.
The results did not demonstrate superiority of one method over the other, with both therapeutic alternatives being satisfactory for the treatment of infertile couples.
宫腔内人工授精（IUI）是一种治疗夫妻不孕症的方法，根据授精精液量，将洗涤后的精子沉积于宫腔或输卵管内。鉴于对授精量存在不同观点，本研究的目的是在两组患者中比较两种技术（3.0 mL或0.5 mL）。
我们进行了164个诱导排卵周期，随后进行宫腔内人工授精。根据使用的技术将患者分为两组。低容量组——50个周期，授精精液量为0.5 mL；高容量组——114个周期，授精精液量为3.0 mL。根据经阴道超声测量的子宫内膜厚度和卵泡发育情况监测周期。在平均直径为18 mm的卵泡出现时给予人绒毛膜促性腺激素（hCG）。使用不连续的PureSperm梯度洗涤精子后40小时进行该操作。
两组的临床妊娠率相似（低容量组为14.0%，高容量组为15.7%）。每组各有1例流产。我们未检测到任何不孕病因或回收的总活动精子对妊娠率有干扰。
结果未显示一种方法优于另一种方法，两种治疗方案对治疗不孕夫妇均令人满意。
