Severus W E, Littman A B, Stoll A L
Psychopharmacology Research Laboratory, McLean Hospital, Belmont, MA, USA.
Harv Rev Psychiatry. 2001 Nov-Dec;9(6):280-93. doi: 10.1080/10673220127910.
Depression is associated with elevated rates of cardiovascular morbidity and mortality. This elevation seems to be due to a significantly increased risk of coronary artery disease and myocardial infarction and, once the ischemic heart disease is established, sudden cardiac death. Recent data suggest that the increased rates of cardiovascular disease in patients with depression may be the result of one or more still-unrecognized underlying physiological factors that predispose a patient to both depression and cardiovascular disease. Two possibly related factors that may have a causal relation with both depressive disorders and cardiovascular disease are an omega-3 fatty acid deficiency and elevated homocysteine levels. We present the available data connecting cardiovascular disease, depression, omega-3 fatty acids, and homocysteine. In addition, we suggest research strategies and some preliminary treatment recommendations that may reduce the increased risk of cardiovascular mortality in patients with major depressive disorder.
抑郁症与心血管疾病的发病率和死亡率升高有关。这种升高似乎是由于冠状动脉疾病和心肌梗死的风险显著增加，并且一旦缺血性心脏病形成，就会导致心源性猝死。最近的数据表明，抑郁症患者心血管疾病发病率的增加可能是一个或多个尚未被认识的潜在生理因素导致的结果，这些因素使患者易患抑郁症和心血管疾病。两个可能与抑郁症和心血管疾病都存在因果关系的相关因素是ω-3脂肪酸缺乏和同型半胱氨酸水平升高。我们展示了将心血管疾病、抑郁症、ω-3脂肪酸和同型半胱氨酸联系起来的现有数据。此外，我们提出了一些研究策略和初步治疗建议，这些建议可能会降低重度抑郁症患者心血管死亡风险的增加。
