Kumar Chandan, Sakshi Pooja, Sinha Niska, Kumar Tarun
Department of Physiology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
Department of Psychiatry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
J Family Med Prim Care. 2024 Jul;13(7):2585-2588. doi: 10.4103/jfmpc.jfmpc_926_23. Epub 2024 Jun 28.
Depression is a common and debilitant mental health disorder that is very common among young adults of the age group of 18-25 years. There is evidence that autonomic nervous system dysfunction associated with depression may play an important role in cardiovascular disease among patients with depression. HRV that is used to assess ANS function is found to be altered in depression. Since the HRV findings associated with depression remain inconsistent, this study is aimed to find HRV changes associated with depression so that the use of HRV as a diagnostic tool for depression can be validated.
A total of 42 newly diagnosed patients of depression of the age group (18-26) years and 89 non-depressed volunteers matched for age, BMI and sex proportions were included in the study. Heart rate variability was recorded using five-minute stationary RR interval of Lead II by 4-channel Power Lab System (AD Instrument Ltd). HRV findings are summarized into Time-Domain parameters, Frequency-Domain parameters and Non-Linear parameters.
All HRV parameters are significantly reduced and the LF/HF ratio is significantly raised ( < 0.05) in the group of depressive patients when compared to the group of healthy controls. The reduction of HRV parameters (SDRR, RMSSD, Total Power, SD1 and SD2) in the group of patients with depression is found to be highly significant ( < 0.0001).
The findings of our study suggest that depression may be associated with alterations in ANS activities, which contribute to an increased risk of cardiovascular disease. Thus, HRV can serve as a potential bio-marker for depression.
抑郁症是一种常见且使人衰弱的心理健康障碍，在18 - 25岁的年轻成年人中非常普遍。有证据表明，与抑郁症相关的自主神经系统功能障碍可能在抑郁症患者的心血管疾病中起重要作用。用于评估自主神经系统功能的心率变异性（HRV）在抑郁症中被发现有所改变。由于与抑郁症相关的HRV研究结果仍不一致，本研究旨在发现与抑郁症相关的HRV变化，以便验证将HRV用作抑郁症诊断工具的可行性。
本研究纳入了42名年龄在（18 - 26）岁的新诊断抑郁症患者以及89名在年龄、体重指数和性别比例上相匹配的非抑郁症志愿者。使用4通道Power Lab系统（AD Instrument Ltd）通过记录II导联五分钟的静态RR间期来记录心率变异性。HRV研究结果总结为时域参数、频域参数和非线性参数。
与健康对照组相比，抑郁症患者组的所有HRV参数均显著降低，且低频/高频比值显著升高（<0.05）。抑郁症患者组中HRV参数（标准差RR、相邻RR间期差值的均方根、总功率、SD1和SD2）的降低被发现具有高度显著性（<0.0001）。
我们的研究结果表明，抑郁症可能与自主神经系统活动的改变有关，这会增加心血管疾病的风险。因此，HRV可作为抑郁症的潜在生物标志物。
