Haist F, Bowden Gore J, Mao H
Laboratory for Research on the Neuroscience of Autism, Children's Hospital Research Center, 8110 La Jolla Shores Drive (Suite 201), La Jolla, California 92037, USA.
Nat Neurosci. 2001 Nov;4(11):1139-45. doi: 10.1038/nn739.
Medial temporal lobe (MTL) lesions typically produce retrograde amnesia characterized by the disproportionate loss of recently acquired memories. Temporally graded memory loss is interpreted traditionally as evidence for a consolidation process guided by the MTL. Here, using functional magnetic resonance imaging (fMRI), we show temporally graded changes in MTL activity in healthy older adults taking a famous faces remote memory test. Evidence for temporally graded change in the hippocampal formation was mixed, suggesting it may participate only in consolidation processes lasting a few years. Entorhinal cortex was associated with temporally graded changes extending up to 20 years. These findings support the basic tenets of consolidation theory and suggest that the entorhinal cortex, rather than the hippocampal formation, participates in memory consolidation over decades.
内侧颞叶（MTL）损伤通常会导致逆行性遗忘，其特征是近期获得的记忆不成比例地丧失。时间梯度性记忆丧失传统上被解释为MTL引导的巩固过程的证据。在这里，我们使用功能磁共振成像（fMRI），在健康的老年人进行著名面孔远程记忆测试时，展示了MTL活动的时间梯度变化。海马结构时间梯度变化的证据不一，表明它可能仅参与持续数年的巩固过程。内嗅皮层与长达20年的时间梯度变化有关。这些发现支持了巩固理论的基本信条，并表明内嗅皮层而非海马结构在数十年的记忆巩固中发挥作用。
