Li J, Wang J, Chen X, Tong S, Fang J, Yu H
Department of Clinical Epidemiology, West China University of Medical Sciences, Chengdu 610041, China.
Chin Med J (Engl). 1999 Jul;112(7):641-5.
To investigate the distribution characteristics of some common and trace elements in both serum and lymphocyte in patients with essential hypertension and to analyse their possible role in the pathogenesis of hypertension.
A cross-sectional study was carried out in 102 hypertensive patients matched with equal number of normotensive subjects by sex, age, and hypertensive family history; all of them were randomly selected from the same community. Both intralymphocytic and serum concentrations of some relevant elements including Na+, K+, Ca2+, Mg2+, Zn2+, Cu2+ and P were measured for all studied subjects, using the inductively coupled plasma spectrometry (ICPS).
The serum and intralymphocytic distribution characteristics of elements in hypertensive patients compared with normotensive controls suggested that there might exist certain defects of the ion-transporting system on cell membrane which might be genetically linked.
探讨原发性高血压患者血清及淋巴细胞中一些常见和微量元素的分布特征，并分析它们在高血压发病机制中的可能作用。
对102例高血压患者进行横断面研究，按性别、年龄和高血压家族史与102例血压正常者进行匹配；所有研究对象均从同一社区随机选取。采用电感耦合等离子体质谱法（ICPS）测定所有研究对象淋巴细胞内及血清中一些相关元素，包括Na⁺、K⁺、Ca²⁺、Mg²⁺、Zn²⁺、Cu²⁺和P的浓度。
1.高血压组淋巴细胞内及血清中Na⁺（分别为P = 0.009、0.004）和Ca²⁺（分别为P = 0.001、0.049）浓度均显著高于血压正常者。2.逐步回归分析显示，收缩压和舒张压与年龄、血清Na⁺/K⁺比值及淋巴细胞内Ca²⁺、Mg²⁺浓度显著相关（两者P均<0.001）。3.根据高血压家族史，对4个亚组采用多因素方差分析方法，结果显示有或无家族史的高血压患者血清Ca²⁺和淋巴细胞内Na⁺浓度均显著高于无家族史的血压正常者。此外，有阳性家族史的血压正常者淋巴细胞内Na⁺浓度显著高于无家族史的血压正常者。
与血压正常对照者相比，高血压患者血清及淋巴细胞内元素分布特征提示，细胞膜离子转运系统可能存在某些缺陷，且可能与遗传有关。
