中国阻塞性睡眠呼吸暂停低通气综合征患者血管紧张素I转换酶基因多态性
Angiotensin I-converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome.
作者信息
Xiao Y, Huang X, Qiu C, Zhu X, Liu Y
机构信息
Department of Respiratory Disease, PUMC Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
出版信息
Chin Med J (Engl). 1999 Aug;112(8):701-4.
OBJECTIVE
To investigate the relationship of an insertion/deletion (I/D) polymorphism of the angiotension-converting enzyme (ACE) gene to obstructive sleep apnea syndrome (OSAS) patients and the control subjects.
METHODS
Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers flanked the polymorphic region in intro 16 of the ACE gene.
RESULTS
OSAS patients had significantly higher frequencies of I/I genotype and insertion allele of the ACE gene as compared with the control subjects in Chinese population. The OSAS patients with I/I genotype had significantly longer apnea time, lower minimum SaO2 and greater AHI than the OSAS patients with I/D genotype.
CONCLUSION
These results indicate that the I/I genotype and I allele are a risk factor for OSAS in Chinese.
目的
探讨血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性与阻塞性睡眠呼吸暂停低通气综合征（OSAS）患者及对照组之间的关系。
方法
从血样中提取基因组DNA，并通过聚合酶链反应（PCR）进行扩增。PCR引物位于ACE基因第16内含子的多态性区域两侧。
结果
在中国人群中，与对照组相比，OSAS患者ACE基因I/I基因型和插入等位基因的频率显著更高。I/I基因型的OSAS患者比I/D基因型的OSAS患者有显著更长的呼吸暂停时间、更低的最低血氧饱和度（SaO2）和更高的呼吸暂停低通气指数（AHI）。
结论
这些结果表明，I/I基因型和I等位基因是中国人患OSAS的危险因素。
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