Cernescu C, Târdei G, Ruţă S, Bleotu C, Alexiu I, Jucu V
Rom J Virol. 1999 Jan-Dec;50(1-4):99-106.
Between April-September 1999 an unusually high number of acute aseptic meningitis was reported in six North Eastern counties of Romania. At the end of 1999 summer the epidemic area extended in South Romania including the Capital City Bucharest. The total number of cases surpassed 5500. The majority of confirmed cases were young children under 15 years of age. More than 1800 cases were registered in the same interval in the neighboring Republic of Moldavia. We report the isolation of ECHO 30 virus from 12 CSF samples of 52 tested on RD and human diploid cells. A small case control study identified high seroneutralization titers confirming a recent ECHO 30 infection in 74% of patient's samples and in 54% of samples from control children tested. The time spent outdoors and poor hygiene practices were prominent risk factors for transmission.
1999年4月至9月期间，罗马尼亚东北部六个县报告了异常大量的急性无菌性脑膜炎病例。1999年夏末，疫情蔓延至罗马尼亚南部，包括首都布加勒斯特。病例总数超过5500例。大多数确诊病例为15岁以下的儿童。在同一时期，邻国摩尔多瓦共和国也登记了1800多例病例。我们报告了从52份脑脊液样本中的12份中分离出埃可30型病毒，这些样本在人横纹肌肉瘤细胞（RD）和人二倍体细胞上进行了检测。一项小型病例对照研究发现，高血清中和滴度证实74%的患者样本和54%接受检测的对照儿童样本近期感染了埃可30型病毒。户外活动时间和不良卫生习惯是传播的主要危险因素。
