分光光度法测定盐酸利托君及其在药物制剂中的应用

Spectrophotometric methods for the determination of ritodrine hydrochloride and its application to pharmaceutical preparations.

作者信息

Revanasiddappa H D, Manju B

机构信息

Department of Studies in Chemistry, University of Mysore, Manasagangotri, India.

出版信息

Farmaco. 2001 Aug;56(8):615-9. doi: 10.1016/s0014-827x(01)01069-2.

DOI:10.1016/s0014-827x(01)01069-2

PMID:11601648

Abstract

Two simple and sensitive spectrophotometric methods are described for the determination of ritodrine hydrochloride (RTH) in both pure and dosage forms. The methods are based on the interaction of diazotised p-nitroaniline (DPNA) and sulphanilic acid (DSNA) with RTH in an alkaline medium. The resulting azo dyes are measured at 480 nm (for the DPNA method) and at 440 nm (for the DSNA method) and are stable for more than 1 h. The optimum reaction conditions and other analytical parameters are evaluated. A study of the effect of commonly associated excipients and additives do not interfere with the determinations. Statistical analysis of results indicates that the methods are precise and accurate.

摘要

本文描述了两种简单且灵敏的分光光度法，用于测定纯品及剂型中的盐酸利托君（RTH）。这些方法基于重氮化对硝基苯胺（DPNA）和磺胺酸（DSNA）在碱性介质中与RTH的相互作用。生成的偶氮染料在480 nm（DPNA法）和440 nm（DSNA法）处进行测定，且在1小时以上保持稳定。评估了最佳反应条件和其他分析参数。对常见辅料和添加剂影响的研究表明它们不干扰测定。结果的统计分析表明这些方法精确且准确。