Department of Medicinal Chemistry, University of Mansoura, Mansoura, 35516, Egypt.
J Fluoresc. 2010 Jan;20(1):251-60. doi: 10.1007/s10895-009-0547-y. Epub 2009 Oct 8.
Simultaneous determination of two structurally related ss(2) adrenergic receptor agonists namely, Ritodrine HCl (RTH) and Isoxsuprine HCl (ISP) was performed using coupling technique of synchronous fluorimetry and H-point standard addition method. Under optimum conditions, linear determination ranges were 1.48 - 14.80 x 10(-6) mol L(-1) and 1.54 - 15.44 x 10(-6) mol L(-1) for ISP and RTH respectively. RTH and ISP could be determined simultaneously without interference from each other when their concentration ratio varies from 5:1 to 1:5 in the mixed sample. The proposed method was applied to the determination of RTH and ISP in synthetic mixture of pharmaceutical samples, the accuracy and precision of the results were satisfactory.
采用同步荧光耦联技术和 H 点标准加入法同时测定了两种结构相关的 ss(2)肾上腺素受体激动剂，即盐酸利托君（RTH）和盐酸异舒普林（ISP）。在最佳条件下，ISP 和 RTH 的线性测定范围分别为 1.48-14.80×10(-6)mol·L(-1)和 1.54-15.44×10(-6)mol·L(-1)。当混合样品中 RTH 和 ISP 的浓度比从 5:1 变化到 1:5 时，它们之间没有相互干扰，可以同时测定。该方法用于合成药物样品混合物中 RTH 和 ISP 的测定，结果准确、精密。
