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N6, O2'-dimethyladenosine a novel methylated ribonucleoside next to the 5' terminal of animal cell and virus mRNAs.

作者信息

Wei C, Gershowitz A, Moss B

出版信息

Nature. 1975 Sep 18;257(5523):251-3. doi: 10.1038/257251a0.

DOI:10.1038/257251a0
PMID:1161029
Abstract
摘要

相似文献

1
N6, O2'-dimethyladenosine a novel methylated ribonucleoside next to the 5' terminal of animal cell and virus mRNAs.N6, O2'-二甲基腺苷,一种位于动物细胞和病毒mRNA 5'末端相邻位置的新型甲基化核糖核苷。
Nature. 1975 Sep 18;257(5523):251-3. doi: 10.1038/257251a0.
2
Sequence of methylated nucleotides at the 5'-terminus of adenovirus-specific RNA.腺病毒特异性RNA 5'端甲基化核苷酸序列。
J Virol. 1976 Feb;17(2):385-92. doi: 10.1128/JVI.17.2.385-392.1976.
3
Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures.流感病毒mRNA在帽结构中含有内部N6-甲基腺苷和5'-末端7-甲基鸟苷。
J Virol. 1976 Oct;20(1):45-53. doi: 10.1128/JVI.20.1.45-53.1976.
4
5'-Terminal and internal methylated nucleosides in herpes simplex virus type 1 mRNA.1型单纯疱疹病毒mRNA中的5'-末端和内部甲基化核苷
J Virol. 1977 Aug;23(2):234-9. doi: 10.1128/JVI.23.2.234-239.1977.
5
Capping structures of simian virus 40 19S and 16S mRNAs.猴病毒40 19S和16S mRNA的帽状结构
Nucleic Acids Res. 1977 Nov;4(11):3959-68. doi: 10.1093/nar/4.11.3959.
6
Methylated 5'-terminal sequences of vaccinia virus mRNA species made in vivo at early and late times after infection.
Virology. 1977 Jun 1;79(1):67-80. doi: 10.1016/0042-6822(77)90335-x.
7
Histone mRNAs contain blocked and methylated 5' terminal sequences but lack methylated nucleosides at internal positions.组蛋白信使核糖核酸含有封闭和甲基化的5'末端序列,但在内部位置缺乏甲基化核苷。
Cell. 1977 Jan;10(1):113-20. doi: 10.1016/0092-8674(77)90145-3.
8
Methylation of adenosine in strongly alkaline medium: Preparation and Properties of o'-methyl derivatives of adenosine and N6-methyladenosine.
Biochemistry. 1976 Jun 29;15(13):2735-40. doi: 10.1021/bi00658a004.
9
Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid.海拉细胞信使核糖核酸N6-甲基腺苷位点的核苷酸序列
Biochemistry. 1977 Apr 19;16(8):1672-6. doi: 10.1021/bi00627a023.
10
Characterization of N6, O2-dimethyladenosine from nuclear RNA of Novikoff hepatoma.诺维科夫肝癌细胞核RNA中N6,O2-二甲基腺苷的特性分析
Nucleic Acids Res. 1978 Mar;5(3):771-6. doi: 10.1093/nar/5.3.771.

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Evidence human FTO catalyses hydroxylation of N6-methyladenosine without direct formation of a demethylated product contrasting with ALKBH5/2/3 and bacterial AlkB.有证据表明,与ALKBH5/2/3和细菌AlkB不同,人类FTO催化N6-甲基腺苷的羟基化反应,但不会直接形成去甲基化产物。
Nucleic Acids Res. 2025 Aug 27;53(16). doi: 10.1093/nar/gkaf813.
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SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice.原发性体感皮层谷氨酸能神经元中SERBP1-PCIF1复合物控制的m6Am修饰是小鼠神经性疼痛所必需的。
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RNA demethylase FTO uses conserved aromatic residues to recognize the mRNA 5' cap and promote efficient mA demethylation.
RNA去甲基化酶FTO利用保守的芳香族残基识别mRNA 5'帽并促进高效的m⁶A去甲基化。
bioRxiv. 2025 May 10:2025.05.09.653100. doi: 10.1101/2025.05.09.653100.
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The Role of Chemical Modifications in the Genome of Negative-Sense RNA Viruses on the Innate Immune Response.化学修饰在负链RNA病毒基因组对天然免疫反应中的作用
Viruses. 2025 May 30;17(6):795. doi: 10.3390/v17060795.
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Chemically modified non-coding RNAs in cancer.癌症中的化学修饰非编码RNA
Expert Rev Mol Med. 2025 Jun 9;27:e19. doi: 10.1017/erm.2025.10007.
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RNA multi-omics in single cells reveal rhythmical RNA reshaping during human and mouse oocyte maturation.单细胞中的RNA多组学揭示了人类和小鼠卵母细胞成熟过程中节律性的RNA重塑。
BMC Biol. 2025 May 28;23(1):147. doi: 10.1186/s12915-025-02250-7.
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RNA modifications and their role in gene expression.RNA修饰及其在基因表达中的作用。
Front Mol Biosci. 2025 Apr 25;12:1537861. doi: 10.3389/fmolb.2025.1537861. eCollection 2025.
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Introduction of human mAm methyltransferase PCIF1 facilitates the biosynthesis of terpenoids in Saccharomyces cerevisiae.人源mAm甲基转移酶PCIF1的引入促进了酿酒酵母中萜类化合物的生物合成。
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The epitranscriptional factor PCIF1 orchestrates CD8 T cell ferroptosis and activation to control antitumor immunity.表观转录因子PCIF1协调CD8 T细胞铁死亡和激活以控制抗肿瘤免疫。
Nat Immunol. 2025 Feb;26(2):252-264. doi: 10.1038/s41590-024-02047-w. Epub 2025 Jan 6.
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mA demethylase CpALKBH regulates mRNA stability to modulate the development and virulence of chestnut blight fungus.mA 去甲基化酶 CpALKBH 调节 mRNA 稳定性以调控栗疫病菌的发育和毒力。
mBio. 2025 Jan 8;16(1):e0184424. doi: 10.1128/mbio.01844-24. Epub 2024 Nov 29.