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粉红病的兴衰

The rise and fall of pink disease.

作者信息

Dally A

机构信息

Wellcome Institute for the History of Medicine, London.

出版信息

Soc Hist Med. 1997 Aug;10(2):291-304. doi: 10.1093/shm/10.2.291.

DOI:10.1093/shm/10.2.291
PMID:11619497
Abstract

This paper explores the social and medical history and context of pink disease (acrodynia), a serious disease of infants and young children that baffled the medical world during the first half of the twentieth century until it was shown to be caused by mercury poisoning. In the English-speaking world the commonest source of the mercury was teething powders, which were widely available and advertised with increasing sophistication. Efforts to control them (such as the BMJ's campaign against 'Secret Remedies') were as yet unsuccessful. The article discusses the social conditions that influenced the existence and recognition of pink disease, the delay in finding its cause, the way in which it was explained as a virus infection or nutritional deficiency and why it seldom occurred outside the teething period. It discusses both professional and lay attitudes to health and diseases during the early twentieth century and provides a model of how the disease developed in a specific social setting and how the medical profession attempted to deal with it within the limitations of contemporary professional thought. The resistance to the evidence of mercury poisoning is typical of resistance to new medical knowledge and declined only when the opponents and sceptics grew old and disappeared from the scene. Meanwhile, the cause having been identified and accepted, pink disease disappeared, but its consequences emerged much later, in an unexpected quarter, as a cause of male infertility.

摘要

本文探讨了粉红病(肢痛症)的社会和医学史及背景,这是一种婴幼儿严重疾病,在20世纪上半叶一直困扰着医学界,直到后来被证明是由汞中毒引起。在英语国家,汞的最常见来源是出牙粉,这类产品随处可得,且广告宣传日益精巧。控制这些产品的努力(如《英国医学杂志》发起的反对“秘方药”运动)尚未成功。本文讨论了影响粉红病存在与认知的社会状况、病因发现的延迟、该病被解释为病毒感染或营养缺乏的方式,以及为何该病很少在出牙期之外出现。文章探讨了20世纪初专业人士和普通大众对健康与疾病的态度,并提供了一个模型,说明该病在特定社会环境中的发展情况,以及医学界如何在当代专业思维的局限内试图应对它。对汞中毒证据的抵制是抵制新医学知识的典型表现,只有当反对者和怀疑者变老并退出舞台时才有所减弱。与此同时,病因被确认并得到认可后,粉红病消失了,但它的后果在很久以后在一个意想不到的领域出现,成为男性不育的一个原因。

相似文献

1
The rise and fall of pink disease.粉红病的兴衰
Soc Hist Med. 1997 Aug;10(2):291-304. doi: 10.1093/shm/10.2.291.
2
The puzzle of pink disease.粉色病之谜。
J R Soc Med. 1999 Sep;92(9):478-81. doi: 10.1177/014107689909200918.
3
Mercury exposure and early effects: an overview.汞暴露与早期影响:概述
Med Lav. 2002 May-Jun;93(3):139-47.
4
Acrodynia and hypertension in a young girl secondary to elemental mercury toxicity acquired in the home.一名年轻女孩因在家中接触元素汞中毒继发肢端痛症和高血压。
Pediatr Dermatol. 2012 Mar-Apr;29(2):199-201. doi: 10.1111/j.1525-1470.2012.01737.x.
5
Ancestry of pink disease (infantile acrodynia) identified as a risk factor for autism spectrum disorders.鉴定出导致婴儿肢端红斑(婴儿肢端痛症)的病因具有患自闭症谱系障碍的风险。
J Toxicol Environ Health A. 2011;74(18):1185-94. doi: 10.1080/15287394.2011.590097.
6
[Mercury in medicine and dentistry. Historical reflection].[医学与牙科中的汞。历史反思]
Tidsskr Nor Laegeforen. 1991 Aug 10;111(18):2235-7.
7
Mercury as a health hazard.汞对健康的危害。
Arch Dis Child. 1987 Mar;62(3):293-5. doi: 10.1136/adc.62.3.293.
8
(PINK DISEASE AND PRIMARY RENAL TUBULAR ACIDOSIS.).
Lancet. 1964 Dec 26;2(7374):1393. doi: 10.1016/s0140-6736(64)91183-3.
9
[Childhood as a value and a problem in the campaigns for health at the beginning of the twentieth century in Spain].[童年作为20世纪初西班牙健康运动中的一种价值观及一个问题]
Dynamis. 1995(15):177-92.
10
PINK DISEASE-TEN YEARS AFTER (THE EPILOGUE).粉色病——十年之后(后记)
Br Med J. 1965 May 1;1(5443):1181-2. doi: 10.1136/bmj.1.5443.1181.

引用本文的文献

1
Systematic Assessment of Research on Autism Spectrum Disorder (ASD) and Mercury Reveals Conflicts of Interest and the Need for Transparency in Autism Research.自闭症谱系障碍 (ASD) 与汞相关研究的系统性评估显示自闭症研究中存在利益冲突和透明度问题。
Sci Eng Ethics. 2017 Dec;23(6):1691-1718. doi: 10.1007/s11948-017-9983-2.
2
Genetic variation associated with hypersensitivity to mercury.与汞超敏反应相关的基因变异。
Toxicol Int. 2014 Sep-Dec;21(3):236-41. doi: 10.4103/0971-6580.155327.
3
The plausibility of a role for mercury in the etiology of autism: a cellular perspective.
汞在自闭症病因学中作用的合理性:细胞层面的视角。
Toxicol Environ Chem. 2011 May;93(5-6):1251-1273. doi: 10.1080/02772248.2011.580588. Epub 2011 May 20.
4
An old autopsy report sheds light on a "new" disease: infantile polyarteritis nodosa and kawasaki disease.一份旧的尸检报告揭示了一种“新”疾病:婴儿结节性多动脉炎和川崎病。
Pediatr Cardiol. 2010 May;31(4):490-6. doi: 10.1007/s00246-009-9625-9. Epub 2010 Jan 7.
5
Pink ladies: mercury poisoning in twin girls.粉红女孩:双胞胎女孩的汞中毒事件
CMAJ. 2003 Jan 21;168(2):201.
6
Biomedical communication and the reaction to the Queensland childhood lead poisoning cases elsewhere in the world.生物医学交流以及世界其他地区对昆士兰儿童铅中毒事件的反应。
Med Hist. 1999 Apr;43(2):155-72. doi: 10.1017/s0025727300065066.
7
The puzzle of pink disease.粉色病之谜。
J R Soc Med. 1999 Sep;92(9):478-81. doi: 10.1177/014107689909200918.