Lau I F, Saksena S K, Chang M C
Prostaglandins. 1975 Jun;9(6):893-900. doi: 10.1016/0090-6980(75)90077-5.
In the female hamster, temporary sterility for a period of 10 or 15 days was induced by an intraperitoneal Silastic-PVP-tube containing 3.5 or 1.0 mg of PGF2alpha, respectively. All Silastic-PVP-PGF2alpha tube hearing animals regained fertility and delivered normal litters at various times after the placement of the tube. The release rate of 3-H-PGF2alpha from the Silastic-PVP tube was described and their potential use as a drug delivery system discussed.
在雌性仓鼠中，分别通过腹腔内植入含有3.5毫克或1.0毫克前列腺素F2α（PGF2α）的硅橡胶-聚乙烯吡咯烷酮（Silastic-PVP）管诱导10天或15天的暂时性不育。所有植入Silastic-PVP-PGF2α管的动物在植入管子后的不同时间恢复生育能力并产下正常的一窝幼崽。描述了3-H-PGF2α从Silastic-PVP管中的释放速率，并讨论了它们作为药物递送系统的潜在用途。
