Saksena S K, Lau I F
Fertil Steril. 1979 Sep;32(3):340-4. doi: 10.1016/s0015-0282(16)44246-9.
In male rabbits of proven fertility, the intrascrotal deposition of two Silastic-polyvinylpyrrolidone tubes containing 3 mg of prostaglandin F2alpha (PGF2alpha)/tube induced within 2 to 4 weeks temporary sterility which lasted for 10 to 14 weeks. Associated with induced sterility were reduction in testicular weight, increase in abnormal spermatozoa (8% to 78% versus 0 to 3.7%), and reduction in sperm motility along the reproductive tract and in the semen for a period of 6 to 7 weeks. During the period of temporary sterility the weight of the epididymis, the sexual drive, and semen volume remained unaltered. Normal fertility was associated with an increase in testicular weight, reduction in the proportion of abnormal sperm, and improved sperm motility. In addition to an altered spermatogenesis, the integrity of mature spermatozoa seemed to be severely affected after PGF2alpha treatment. The reduced number of viable young sired by males that recovered from temporary sterility (pregnancy wastage 35%) as compared with sham-treated controls (pregnancy wastage 3%) suggests that a small percentage of spermatozoa might still be defective at the time of testing. A longer waiting period might be needed to ensure a completely normal reproductive process.
在经证实具有生育能力的雄性兔子中，在阴囊内植入两根含有3毫克前列腺素F2α（PGF2α）/管的硅橡胶-聚乙烯吡咯烷酮管，在2至4周内可诱导暂时性不育，持续10至14周。与诱导不育相关的是睾丸重量减轻、异常精子增加（8%至78%，而对照组为0至3.7%），以及在6至7周的时间里，生殖道和精液中的精子活力降低。在暂时性不育期间，附睾重量、性欲和精液量保持不变。正常生育能力与睾丸重量增加、异常精子比例降低以及精子活力提高有关。除了精子发生改变外，PGF2α治疗后成熟精子的完整性似乎也受到严重影响。与假手术对照组（妊娠损失率3%）相比，从暂时性不育中恢复的雄性兔子所产活仔数量减少（妊娠损失率35%），这表明在测试时仍有一小部分精子可能存在缺陷。可能需要更长的等待期来确保生殖过程完全正常。
