Hannay W T, Sharp F, Parman M G, McAllister T A
Scott Med J. 1975 Jul;20(4):175-7. doi: 10.1177/003693307502000414.
The pharmacodynamics of a new cephalosporin--cephazolin--have been evaluated in clinical obstetrics with particular reference to antibiotic prophylaxis for the cardiac patient, and the prophylaxis and treatment of choriamnionitis and intrauterine pneumonia. Cephazolin effectively crosses the placental barrier. It slowly concentrates in the amniotic fluid when the fetus is alive. This new drug may be used for phophylactic cover in the above clinical situations.
一种新型头孢菌素——头孢唑林——的药效学已在临床产科中进行了评估，特别涉及对心脏病患者的抗生素预防，以及绒毛膜羊膜炎和宫内肺炎的预防与治疗。头孢唑林能有效穿过胎盘屏障。当胎儿存活时，它会缓慢在羊水中蓄积。这种新药可用于上述临床情况的预防性用药。
