Craft I, Mullinger B M, Kennedy M R
Br J Obstet Gynaecol. 1981 Feb;88(2):141-5. doi: 10.1111/j.1471-0528.1981.tb00958.x.
The transfer of cefuroxime across the placenta was studied in 10 women in labour and 12 women being delivered by Caesarean section. Following a single intramuscular injection of 750 mg cefuroxime, high antibiotic concentrations were found in the amniotic fluid in women in labour; the peak concentration of 18 mg/l was achieved after five hours. Therapeutic concentrations of cefuroxime were present in umbilical vein serum for up to eight hours after injection. A similar pharmacokinetic picture was observed in the women undergoing Caesarean section although in the limited time interval (up to four hours) between injection and delivery the amniotic fluid levels of cefuroxime achieved were lower. Cefuroxime appears to cross the placenta well to produce effective concentrations in fetal blood and amniotic fluid.
对10名分娩期妇女和12名剖宫产妇女进行了头孢呋辛透过胎盘情况的研究。单次肌内注射750mg头孢呋辛后，分娩期妇女羊水内发现高浓度抗生素；5小时后达到峰值浓度18mg/L。注射后长达8小时脐静脉血清中存在治疗浓度的头孢呋辛。剖宫产妇女中观察到类似的药代动力学情况，尽管在注射与分娩之间的有限时间间隔（长达4小时）内，头孢呋辛的羊水水平较低。头孢呋辛似乎能很好地透过胎盘，在胎儿血液和羊水中产生有效浓度。
