Tholozan arrived in Persia in 1858 and remained there until his death in 1897. Personal physician of Nasreddin Shah with the title of hakim bachi, he was also appointed director of the Medical School of Teheran founded in 1850. He trained many Persian physicians and wrote medical treatises printed in persian. In 1866 he married in Teheran a widow of greco-italian origin from whom he had a daughter, Elise, who will have many descendants. Besides his important monographs on epidemic diseases (plague, cholera, etc.) Tholozan wrote in 1869 a "Rapport a S.M. le Shah sur l'etat de l'hygiene en Perse". He accompanied the Shah during his three voyages in Europe (1873, 1878, 1889) and stayed for his health three years in France after the last one, being replaced by Dr. Feuvrier as physician of the Shah. The friendly relations between Tholozan and the French archeologists Marcel and Jane Dieulafoy for whom he obtained from the Shah the permission to undertake diggings at Susa are recalled with the help of unpublished documents.
托洛赞于1858年抵达波斯，一直待到1897年去世。他是纳赛尔丁·沙阿的私人医生，头衔是首席御医，还被任命为1850年成立的德黑兰医学院院长。他培养了许多波斯医生，并撰写了用波斯语印刷的医学论文。1866年，他在德黑兰与一位希腊-意大利裔寡妇结婚，育有一女，名叫伊莉斯，她有许多后代。除了关于流行病（鼠疫、霍乱等）的重要专著外，托洛赞于1869年撰写了一份《给国王陛下关于波斯卫生状况的报告》。他在国王的三次欧洲之行（1873年、1878年、1889年）中陪同，最后一次出行后因健康原因在法国待了三年，之后由费夫里尔医生接替他担任国王的御医。借助未发表的文件，人们回忆起了托洛赞与法国考古学家马塞尔和简·迪厄拉富瓦之间的友好关系，他为他们从国王那里获得了在苏萨进行挖掘的许可。
