Smith C D, Furcolow M L, Hulker P W
Sabouraudia. 1975 Jul;13(2):192-9.
Reported is a short term (16 week) experiment to determine the distribution of B. dermatitidis in dogs when infected by the natural inhalation route by receiving about 250,000 viable particles during a 24h. exposure. Four dogs were positive to blastomycin and 1 to histoplasmin prior to exposure. Post exposure, all dogs developed positive skin tests to blastomycin by the 4th week with considerable cross reaction to histoplasmin. Serologic tests showed more poritive CF tests to Histoplasma than to Blastomyces so that the test appears of no practical value. Although 22 tissues were cultured on each dog, only 1 or 7 dogs was positive for B. dermatitidis by 2 weeks. At 4 weeks, 57% of the dogs were positive by culture and at 12, 15, and 16 weeks, all were positive. One dog developed eye lesions and became emaciated.
报告了一项短期（16周）实验，该实验旨在确定犬类通过自然吸入途径感染皮炎芽生菌后的分布情况，在24小时暴露期间接受约250,000个活颗粒。暴露前，4只犬对芽生菌素呈阳性反应，1只犬对组织胞浆菌素呈阳性反应。暴露后，所有犬在第4周时对芽生菌素皮肤试验呈阳性，对组织胞浆菌素有相当程度的交叉反应。血清学检测显示，对组织胞浆菌的补体结合试验阳性比对芽生菌的更多，因此该试验似乎没有实际价值。尽管每只犬的22个组织进行了培养，但在2周时只有1只或7只犬的皮炎芽生菌呈阳性。在4周时，57%的犬通过培养呈阳性，在12周、15周和16周时，所有犬均呈阳性。1只犬出现眼部病变并消瘦。
