Prasad D R, Zimmerman S W, Burkholder P M
Arch Pathol Lab Med. 1977 Jul;101(7):345-9.
To assess the role of immune mechanisms in the pathogenesis of minimal-change nephrotic syndrome (MCNS), immunohistologic studies were performed on renal biopsy specimens from 31 patients. Glomerular immunoglobulin and/or complement (C3) deposition was present in 20 specimens. Deposits were usually minimal to moderate, granular, and focal in nature. IgM was present in 17 specimens, C3 in 10, IgG in 8 and IgA in only 3. With a mean follow-up of 5 1/2 years, there is no difference in the response to therapy of patients with no glomerular immunoglobulin or C3, those with glomerular immunoglobulin without C3, and those with glomerular C3. These findings indicate that glomerular immune deposits can be seen in a substantial percentage of patients with MCNS, but the minimal and focal nature of the deposits and lack of correlation with response to therapy suggest that immunoglobulin and C3 deposits are nonspecific and have no pathogenetic role.
为评估免疫机制在微小病变型肾病综合征（MCNS）发病机制中的作用，对31例患者的肾活检标本进行了免疫组织学研究。20份标本中存在肾小球免疫球蛋白和/或补体（C3）沉积。沉积物通常为轻度至中度，呈颗粒状且为局灶性。17份标本中有IgM，10份中有C3，8份中有IgG，仅有3份中有IgA。平均随访5.5年，无肾小球免疫球蛋白或C3的患者、有肾小球免疫球蛋白但无C3的患者以及有肾小球C3的患者对治疗的反应无差异。这些发现表明，相当比例的MCNS患者可出现肾小球免疫沉积物，但沉积物的微小和局灶性以及与治疗反应缺乏相关性表明，免疫球蛋白和C3沉积是非特异性的，无致病作用。
