Stone W J, Warnock L G, Wagner C
Am J Clin Nutr. 1975 Sep;28(9):950-7. doi: 10.1093/ajcn/28.9.950.
Significant decreases in plasma pyridoxal-5-phosphate (PLP), plasma glutamic-oxaloacetic transaminase (PGOT) and erythrocyte glutamic-oxaloacetic transaminase (EGOT) were found in 29 uremic patients including 14 who had been on hemodialysis an average of 15.8 months. The mean PLP values of the uremic patients (5.39 +/- 0.37 ng/ml) were clearly lower than the values obtained for the normal group (9.30 +/- 0.80 mg/ml). The mean PGOT values of the uremic patients (dialyzed 4.07 +/- 0.29 U/liter, undialyzed 5.31 +/- 0.49 U/liter) were significantly lower than the normal group (6.57 +/- 0.39 U/liter). The mean EGOT value of the uremic patients (325 +/- 17 U/liter) was also lower than normal subjects (416 +/-21 U/liter). Stimulation of the EGOT by exogenous PLP (EGOT index) was less in dialyzed patients (1.60) than normal subjects (1.80) while the undialyzed uremic subjects had a greater than normal stimulation (2.12). All of these results indicate that uremic patients are vitamin B6 deficient and that those undergoing hemodialysis may have decreased amounts of the EGOT apoenzyme.
在29例尿毒症患者中发现血浆磷酸吡哆醛（PLP）、血浆谷草转氨酶（PGOT）和红细胞谷草转氨酶（EGOT）显著降低，其中14例患者平均接受了15.8个月的血液透析。尿毒症患者的平均PLP值（5.39±0.37 ng/ml）明显低于正常组（9.30±0.80 mg/ml）。尿毒症患者的平均PGOT值（透析患者为4.07±0.29 U/升，未透析患者为5.31±0.49 U/升）显著低于正常组（6.57±0.39 U/升）。尿毒症患者的平均EGOT值（325±17 U/升）也低于正常受试者（416±21 U/升）。外源性PLP对EGOT的刺激作用（EGOT指数）在透析患者中（1.60）低于正常受试者（1.80），而未透析的尿毒症患者则有高于正常的刺激作用（2.12）。所有这些结果表明，尿毒症患者存在维生素B6缺乏，且接受血液透析的患者可能EGOT脱辅基酶量减少。
