Tanaka M, Kosakai M, Inomata I, Takaki K, Ishikawa E
Acta Pathol Jpn. 1976 Sep;26(5):581-8. doi: 10.1111/j.1440-1827.1976.tb00515.x.
Inorder to gain a foothold in clarifying the functional significance of fatstoring cells, an enzyme histochemical study on these cells was carried out. Fat-storing cells showed no alkaline phosphatase, acid phosphatase or esterase activity but demonstrated a marked gamma-glutamyl transpeptidase activity suggesting the possibility of its participation in the synthesis of fiber protein. This possibility was further heightened by its remarkable activity noted at the site of progressive fibrosis. Fat-storing cells under a normal condition partake in the formation of fibers supporting the sinusoidal wall, and under an abnormal condition gradually change their shape with loss of fat droplets and then transform into fibroblast-like cells closely related to the progress of fibrosis.
为了在阐明贮脂细胞的功能意义方面取得进展，对这些细胞进行了酶组织化学研究。贮脂细胞未显示碱性磷酸酶、酸性磷酸酶或酯酶活性，但显示出明显的γ-谷氨酰转肽酶活性，提示其可能参与纤维蛋白的合成。在进行性纤维化部位观察到的显著活性进一步增强了这种可能性。正常情况下，贮脂细胞参与支持窦壁的纤维形成，在异常情况下，它们逐渐改变形状，脂肪滴丢失，然后转化为与纤维化进展密切相关的成纤维细胞样细胞。
