Lo J N, Cumming J F
Anesthesiology. 1975 Sep;43(3):307-12. doi: 10.1097/00000542-197509000-00007.
Premedication with diazepam, hydroxyzine or secobarbital significantly increased ketamine-induced sleep time (137 +/- 3.5 min, 135 +/- 9.2 min, 128 +/- 4.7 min) over that of unpremedicated controls (98.5 +/- 4.4 min) in man. The corresponding mean plasma half-lives (t1/2) of ketamine were longer in patients premedicated with diazepam or seconbarbital (57.8 +/- 4.9 min, 46 +/- 3.2 min) than in controls (36 +/- 1.8 min). Ketamine t1/2 in the perfusate of isolated, perfused rat livers was prolonged 30 to 50 per cent by addition of diazepam, secobarbital, or hydroxyzine. The data suggest that these commonly used premedicants decrease the rate of ketamine metabolism.
在人体中，使用地西泮、羟嗪或司可巴比妥进行术前用药，与未进行术前用药的对照组（98.5±4.4分钟）相比，显著延长了氯胺酮诱导的睡眠时间（分别为137±3.5分钟、135±9.2分钟、128±4.7分钟）。术前用地西泮或司可巴比妥用药的患者，氯胺酮相应的平均血浆半衰期（t1/2）（分别为57.8±4.9分钟、46±3.2分钟）比对照组（36±1.8分钟）更长。在离体灌注大鼠肝脏的灌注液中，加入地西泮、司可巴比妥或羟嗪可使氯胺酮的t1/2延长30%至50%。数据表明，这些常用的术前用药会降低氯胺酮的代谢速率。
