Kruysse A, Feron V J, Til H P
Arch Environ Health. 1975 Sep;30(9):449-52. doi: 10.1080/00039896.1975.10666748.
The subacute inhalation toxicity of acetaldehyde was examined with four groups of 20 hamsters each, exposed repeatedly to acetaldehyde vapor at concentrations of 0, 390, 1,340, and 4,560 ppm (six hr day, five days/week) for a 90-day period. The highest level induced growth retardation, ocular and nasal irritation, increased numbers of erythrocytes, increased weights of heart and kidneys, and severe histopathological changes in the respiratory tract that mainly consisted of necrosis, inflammatory changes, and hyper- and metaplasia of the epithelium. The upper segments of the respiratory tract were much more severely injured than the lower parts. At 1,340 ppm treatment-releated changes included increased kidney weights in males and slight hyper- and metaplastic changes of the tracheal epithelium; 390 ppm was considered a no toxic effect level.
用四组每组20只仓鼠研究乙醛的亚急性吸入毒性，在90天内，仓鼠每天反复暴露于浓度为0、390、1340和4560 ppm的乙醛蒸气中（每天6小时，每周5天）。最高浓度组出现生长迟缓、眼鼻刺激、红细胞数量增加、心脏和肾脏重量增加，以及呼吸道严重的组织病理学变化，主要包括坏死、炎症变化以及上皮细胞的增生和化生。呼吸道上段比下段损伤严重得多。在1340 ppm浓度下，与处理相关的变化包括雄性仓鼠肾脏重量增加以及气管上皮轻微的增生和化生变化；390 ppm被认为是无毒性作用水平。
