Feron V J, Kruysse A, Til H P, Immel H R
Toxicology. 1978 Feb;9(1-2):47-57. doi: 10.1016/0300-483x(78)90030-6.
The subacute inhalation toxicity of acrolein was examined in 4 groups of 20 hamsters, 12 rats and 4 rabbits each, exposed repeatedly to acrolein vapour at concentrations of 0, 0.4, 1.4 and 4.9 ppm (6 h/day, 5 days/week) for a 13-week period. The most important effects found at the highest level included mortality in rats, ocular and nasal irritation, growth depression and histopathological changes of the respiratory tract in each of the animal species exposed. The aberrations in the airways consisted of destruction and hyper- and metaplasia of the lining epithelium accompanied by inflammatory alterations. Rats appeared to be the most susceptible of the species examined and showed treatment-related abnormalities even at 0.4 ppm, whereas this exposure level was found to be a no-toxic effect level in both hamsters and rabbits.
对4组实验动物进行了丙烯醛的亚急性吸入毒性研究，每组分别有20只仓鼠、12只大鼠和4只兔子，在13周的时间里，每周5天、每天6小时反复暴露于浓度为0、0.4、1.4和4.9 ppm的丙烯醛蒸气中。在最高暴露水平下发现的最重要影响包括大鼠死亡、眼鼻刺激、生长抑制以及所有暴露动物物种的呼吸道组织病理学变化。气道异常包括衬里上皮的破坏、增生和化生，并伴有炎症改变。在所研究的物种中，大鼠似乎最为敏感，即使在0.4 ppm时也出现了与处理相关的异常，而该暴露水平对仓鼠和兔子均为无毒性效应水平。
