Effect of hydroxylamine on the consequences of long-lasting administration of morphine in mice. III. Effect on preferred drinking of morphine solution.

C57BL/6J mice were periodically required to drink a morphine solution for one, ten or sixteen weeks and then injected intracranially with the mutagens hydroxylamine or sodium nitrite. Whereas before the injection of the drugs the mice demonstrated a definite preference for morphine, after hydroxylamine this preference disappeared. Sodium nitrite had no such effect on the consumption of morphine solution.