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羟胺对小鼠长期给予吗啡后果的影响。III. 对吗啡溶液偏好性饮水的影响。

Effect of hydroxylamine on the consequences of long-lasting administration of morphine in mice. III. Effect on preferred drinking of morphine solution.

作者信息

Reinis S

出版信息

Arch Int Pharmacodyn Ther. 1975 Jun;215(2):238-45.

PMID:1164090
Abstract

C57BL/6J mice were periodically required to drink a morphine solution for one, ten or sixteen weeks and then injected intracranially with the mutagens hydroxylamine or sodium nitrite. Whereas before the injection of the drugs the mice demonstrated a definite preference for morphine, after hydroxylamine this preference disappeared. Sodium nitrite had no such effect on the consumption of morphine solution.

摘要

C57BL/6J小鼠被定期要求饮用吗啡溶液1周、10周或16周，然后颅内注射诱变剂羟胺或亚硝酸钠。在注射药物之前，小鼠对吗啡表现出明确的偏好，而注射羟胺后这种偏好消失了。亚硝酸钠对吗啡溶液的消耗没有这种影响。

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Effect of hydroxylamine on the consequences of long-lasting administration of morphine in mice. III. Effect on preferred drinking of morphine solution.羟胺对小鼠长期给予吗啡后果的影响。III. 对吗啡溶液偏好性饮水的影响。
Arch Int Pharmacodyn Ther. 1975 Jun;215(2):238-45.
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