Giese K P, Friedman E, Telliez J B, Fedorov N B, Wines M, Feig L A, Silva A J
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Neuropharmacology. 2001 Nov;41(6):791-800. doi: 10.1016/s0028-3908(01)00096-x.
Previous results have suggested that the Ras signaling pathway is involved in learning and memory. Ras is activated by nucleotide exchange factors, such as the calmodulin-activated guanine-nucleotide releasing factor 1 (Ras-GRF1). To test whether Ras-GRF1 is required for learning and memory, we inactivated the Ras-GRF1 gene in mice. These mutants performed normally in a rota-rod motor coordination task, and in two amygdala-dependent tasks (inhibitory avoidance and contextual conditioning). In contrast the mutants were impaired in three hippocampus-dependent learning tasks: contextual discrimination, the social transmission of food preferences, and the hidden-platform version of the Morris water maze. These studies indicate that Ras-GRF1 plays a role in hippocampal-dependent learning and memory.
先前的研究结果表明，Ras信号通路参与学习和记忆过程。Ras由核苷酸交换因子激活，例如钙调蛋白激活的鸟嘌呤核苷酸释放因子1（Ras-GRF1）。为了测试Ras-GRF1是否是学习和记忆所必需的，我们使小鼠体内的Ras-GRF1基因失活。这些突变体在转棒式运动协调任务以及两项杏仁核依赖的任务（抑制性回避和情境条件反射）中表现正常。相比之下，这些突变体在三项海马体依赖的学习任务中受损：情境辨别、食物偏好的社会传递以及莫里斯水迷宫的隐藏平台版本。这些研究表明，Ras-GRF1在海马体依赖的学习和记忆中发挥作用。
