体重指数的增加能否解释儿童哮喘的上升趋势？
Can the increase in body mass index explain the rising trend in asthma in children?
作者信息
Chinn S, Rona R J
机构信息
Department of Public Health Sciences, King's College London, London SE1 3QD, UK.
出版信息
Thorax. 2001 Nov;56(11):845-50. doi: 10.1136/thorax.56.11.845.
BACKGROUND
The reported association between asthma and obesity and the documented rise in each over time have led to suggestions that rising obesity might explain the increase in the prevalence of asthma. Trends in both in British children participating in the National Study of Health and Growth were marked from 1982 to 1994.
METHODS
Odd ratios for trends in asthma and symptoms in 8 and 9 year old children were calculated with and without adjustment for body mass index (BMI).
RESULTS
In a representative sample of white children the odds ratio per year for asthma was 1.09 (95% CI 1.07 to 1.11) before and after adjustment for BMI for boys and 1.09 (95% CI 1.07 to 1.12) and 1.09 (95% CI 1.05 to 1.12), respectively, for girls. Unadjusted and adjusted odds ratios were also virtually identical for wheeze and "asthma or bronchitis". The lack of effect of adjustment was due to a change in the association between BMI and symptoms with time.
CONCLUSIONS
Trends in overweight and obesity do not explain the increase in asthma. The evidence points towards the association between asthma and obesity being of recent origin. This may be explained by obesity being a marker of recent lifestyle differences now associated with both asthma and overweight.
背景
据报道，哮喘与肥胖之间存在关联，且二者的发病率均随时间上升，这使得有人认为肥胖率上升可能是哮喘患病率增加的原因。1982年至1994年间，参与全国健康与成长研究的英国儿童在这两方面的趋势都很明显。
方法
计算8岁和9岁儿童哮喘及相关症状趋势的比值比，计算时分别对体重指数（BMI）进行了调整和未调整。
结果
在白人儿童的代表性样本中，男孩调整BMI前后哮喘的每年比值比为1.09（95%可信区间1.07至1.11），女孩分别为1.09（95%可信区间1.07至1.12）和1.09（95%可信区间1.05至1.12）。喘息和“哮喘或支气管炎”的未调整和调整后比值比也几乎相同。调整无效果是由于BMI与症状之间的关联随时间发生了变化。
结论
超重和肥胖的趋势并不能解释哮喘发病率的增加。有证据表明哮喘与肥胖之间的关联是近期才出现的。这可能是因为肥胖是近期生活方式差异的一个标志，而这种差异现在与哮喘和超重都有关联。
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