环境干扰对大鼠血浆未酯化脂肪酸和色氨酸浓度的快速影响及其通过抗多聚药物的预防作用。
Rapid effects of environmental disturbance on rat plasma unesterified fatty acid and tryptophan concentrations and their prevention by antilopolytic drugs.
作者信息
Curzon G, Knott P J
出版信息
Br J Pharmacol. 1975 Jul;54(3):389-96. doi: 10.1111/j.1476-5381.1975.tb07580.x.
1 Changes of plasma unesterified fatty acid (UFA) and tryptophan concentration in group-housed rats following removal of their cage-mates and the effects of antilipolytic drugs on these changes were investigated. 2 Removal of group-housed 24 h fasted rats but not fed rats from cages resulted in increased plasma UFA concentration in the remaining rats which was associated with significant increases of the proportion of free tryptophan but significant falls of total tryptophan concentration. These rapid changes were not associated with brain tryptophan changes. Plasma tyrosine concentration was unaffected. 3 The fall of plasma tryptophan did not appear to be due to passage into red cells as erythrocyte tryptophan concentration remained unchanged. 4 Plasma UFA concentrations correlated positively and significantly with corticosterone concentrations which were also increased following removal of cage-mates. 5 Plasma UFA increases and tryptophan changes in the fasting rats were both prevented by nicotinic acid or propranolol. Corticosterone concentration was increased by nicotinic acid but unaffected by propranolol. 6 The possible importance of these rapid changes of plasma tryptophan and of their prevention by antilipolytic drugs is discussed.
1 研究了群居大鼠被移出同笼伙伴后血浆非酯化脂肪酸（UFA）和色氨酸浓度的变化，以及抗脂解药物对这些变化的影响。2 将群居且禁食24小时的大鼠而非进食大鼠从笼中移出，导致其余大鼠血浆UFA浓度升高，这与游离色氨酸比例显著增加但总色氨酸浓度显著下降有关。这些快速变化与脑内色氨酸变化无关。血浆酪氨酸浓度未受影响。3 血浆色氨酸的下降似乎并非由于进入红细胞，因为红细胞色氨酸浓度保持不变。4 血浆UFA浓度与皮质酮浓度呈显著正相关，在移出同笼伙伴后皮质酮浓度也升高。5 烟酸或普萘洛尔可预防禁食大鼠血浆UFA升高和色氨酸变化。烟酸可使皮质酮浓度升高，但普萘洛尔对其无影响。6 讨论了血浆色氨酸这些快速变化及其被抗脂解药物预防的可能重要性。
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