Lobl R T
J Endocrinol. 1975 Jul;66(1):79-84. doi: 10.1677/joe.0.0660079.
Total nuclear uptake of oestradiol, specific nuclear binding of oestradiol and oestrogen-induced proteins were studied in the uterus of femal Sprague-Dawley rats injected on postnatal day 3 with sesame oil or with 1-25 mg of testosterone propionate in sesame oil (androgenization). Total uptake of radioactivity was lower than normal in nuclei from uterine homogenates of androgenized females but was increased by the addition of excess cytosol from normal uterus. These data suggest that androgenization increases the uterine cytosol proteins which inhibit translocation of oestradiol to the cellnucleus. Androgenization also reduced specific (5 S) nuclear binding of oestradiol and the formation of estrogen-induced proteins.
在出生后第3天给雌性斯普拉格-道利大鼠注射芝麻油或注射含1 - 25毫克丙酸睾酮的芝麻油（雄激素化）后，研究雌二醇的总核摄取、雌二醇的特异性核结合以及雌激素诱导蛋白。雄激素化雌性大鼠子宫匀浆细胞核中的放射性总摄取低于正常水平，但加入正常子宫的过量胞质溶胶后则增加。这些数据表明，雄激素化增加了子宫胞质溶胶蛋白，从而抑制雌二醇向细胞核的转运。雄激素化还降低了雌二醇的特异性（5S）核结合以及雌激素诱导蛋白的形成。
