Quandt S A, Arcury T A, Preisser J S, Bernert J T, Norton D
Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1064, USA.
J Occup Environ Med. 2001 Oct;43(10):844-52. doi: 10.1097/00043764-200110000-00003.
We report the results of a cohort study of 182 seasonal and migrant farmworkers engaged in tobacco production in two North Carolina counties. Data were collected on tobacco work tasks and risk factors for exposure to nicotine, including smoking, every 2 weeks over a 10-week period during the summer of 1999. Saliva samples were collected for cotinine analysis at every contact. Salivary cotinine levels increased across the season, independent of smoking status. Multivariate analyses identified a model (R2 = 0.68) in which predictors of cotinine included greater age, later-season work, wet working conditions, smoking, and work task. Harvesting ("priming") tobacco was associated with higher cotinine levels than other tasks. This study demonstrates that tobacco workers experience substantial work-related exposure to nicotine. The long-term effects of such exposure should be investigated.
我们报告了一项队列研究的结果，该研究针对北卡罗来纳州两个县的182名从事烟草生产的季节性和流动农场工人。在1999年夏季为期10周的时间里，每两周收集一次有关烟草工作任务以及接触尼古丁的风险因素（包括吸烟情况）的数据。每次接触时都采集唾液样本用于可替宁分析。整个季节中唾液可替宁水平均有上升，与吸烟状况无关。多变量分析确定了一个模型（R2 = 0.68），其中可替宁的预测因素包括年龄较大、季节后期工作、潮湿的工作条件、吸烟以及工作任务。采摘（“打顶”）烟草与比其他任务更高的可替宁水平相关。这项研究表明，烟草工人在工作中会大量接触尼古丁。应调查这种接触的长期影响。
