Barr Dana B, Thomas Kent, Curwin Brian, Landsittel Doug, Raymer James, Lu Chensheng, Donnelly K C, Acquavella John
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Environ Health Perspect. 2006 Jun;114(6):936-42. doi: 10.1289/ehp.8527.
Although biomonitoring has been used in many occupational and environmental health and exposure studies, we are only beginning to understand the complexities and uncertainties involved with the biomonitoring process--from study design, to sample collection, to chemical analysis--and with interpreting the resulting data. We present an overview of concepts that should be considered when using biomonitoring or biomonitoring data, assess the current status of biomonitoring, and detail potential advancements in the field that may improve our ability to both collect and interpret biomonitoring data. We discuss issues such as the appropriateness of biomonitoring for a given study, the sampling time frame, temporal variability in biological measurements to nonpersistent chemicals, and the complex issues surrounding data interpretation. In addition, we provide recommendations to improve the utility of biomonitoring in farmworker studies.
尽管生物监测已被用于许多职业与环境卫生及暴露研究,但我们才刚刚开始理解生物监测过程所涉及的复杂性和不确定性——从研究设计、样本采集到化学分析——以及解读所得数据。我们概述了在使用生物监测或生物监测数据时应考虑的概念,评估了生物监测的现状,并详细介绍了该领域可能提高我们收集和解读生物监测数据能力的潜在进展。我们讨论了诸如生物监测对特定研究的适用性、采样时间框架、生物测量中对非持久性化学物质的时间变异性以及围绕数据解读的复杂问题等。此外,我们还提供了提高生物监测在农场工人研究中效用的建议。