Bodner K M, Burns C J, Randolph N M, Salazar E J
Dow Chemical Company, Epidemiology, EH&S, 1803 Building, Midland, MI 48674, USA.
J Occup Environ Med. 2001 Oct;43(10):890-7. doi: 10.1097/00043764-200110000-00008.
A longitudinal comparison of 305 toluene diisocyanate (TDI) and 581 hydrocarbons workers employed at a Texas chemical manufacturing facility from 1971 through 1997 tested whether workplace exposure to TDI was associated with changes in any of the respiratory measures collected by the company's health surveillance program. Mean TDI exposures measured 96.9 ppb-months, or 2.3 ppb per job. At the end of the study, there were no differences in self-reported symptoms between the groups. Longitudinal analyses of symptoms and pulmonary function showed no correlation with TDI exposure, yielding an average annual decrease in forced expiratory volume at 1 second of 30 mL per year. We concluded that exposure to TDI at workplace concentrations was not associated with respiratory illnesses in this cohort, and consistent with other recent research, it seemed not to accelerate the normal age-related decline in pulmonary function.
对1971年至1997年期间在得克萨斯州一家化学制造工厂工作的305名甲苯二异氰酸酯（TDI）工人和581名碳氢化合物工人进行了纵向比较，以测试工作场所接触TDI是否与公司健康监测计划收集的任何呼吸指标变化有关。测得的TDI平均暴露量为96.9 ppb-月，即每份工作2.3 ppb。在研究结束时，两组之间自我报告的症状没有差异。对症状和肺功能的纵向分析表明，与TDI暴露没有相关性，1秒用力呼气量平均每年下降30 mL。我们得出结论，在该队列中，工作场所浓度的TDI暴露与呼吸系统疾病无关，并且与其他近期研究一致，似乎不会加速与年龄相关的肺功能正常下降。
