甲苯二异氰酸酯生产工人肺功能的纵向和横断面分析。
Longitudinal and Cross-sectional Analyses of Lung Function in Toluene Diisocyanate Production Workers.
机构信息
National Institute for Occupational Safety and Health, Morgantown, West Virginia (Drs Wang [former affiliation], Storey, Doney); Medical College of Wisconsin, Milwaukee, Wisconsin (Dr Cassidy); BASF-The Chemical Company, Florham Park, New Jersey (Dr Conner [former affiliation]); DOW Chemical Company, Midland, Michigan (Drs Collins, Carson [former affiliations]); Saginaw Valley State University, University City, Michigan (Dr Collins); and Covestro LLC (formerly known as Bayer MaterialScience LLC), Pittsburgh, Pennsylvania (Dr Molenaar [former affiliation]).
出版信息
J Occup Environ Med. 2017 Dec;59 Suppl 12(Suppl 12):S28-S35. doi: 10.1097/JOM.0000000000001124.
OBJECTIVE
The aim of this study was to investigate lung function among toluene diisocyanate (TDI) production workers.
METHODS
One hundred ninety-seven U.S workers performed spirometry from 2006 through 2012. Results were compared within the study cohort and with U.S. population measures. A mixed-effects model assessed factors affecting repeated forced expiratory volume in 1 second (FEV1) measurements.
RESULTS
The cohort's mean FEV1 and forced vital capacity (FVC) percent reference values, although greater than 90%, were significantly lower and the prevalence of abnormal spirometry (predominantly restrictive pattern) was significantly higher than in the U.S.
POPULATION
Differences in lung function among workers with higher cumulative TDI exposure were in the direction of an exposure effect, but not significant.
CONCLUSION
We found little evidence of an adverse effect of TDI exposure on longitudinal spirometry in these workers. The association between TDI exposure and the increasing prevalence of a restrictive pattern needs further exploration.
目的
本研究旨在调查甲苯二异氰酸酯（TDI）生产工人的肺功能。
方法
197 名美国工人于 2006 年至 2012 年期间进行了肺活量测定。将研究队列内的结果与美国人群测量值进行了比较。混合效应模型评估了影响重复用力呼气量（FEV1）测量的因素。
结果
该队列的平均 FEV1 和用力肺活量（FVC）%参考值虽然大于 90%，但明显较低，且异常肺活量测定（主要为限制性模式）的患病率明显高于美国。
人群
累积 TDI 暴露量较高的工人之间的肺功能差异呈暴露效应方向，但无统计学意义。
结论
我们在这些工人中几乎没有发现 TDI 暴露对纵向肺活量测定有不良影响的证据。TDI 暴露与限制性模式患病率增加之间的关联需要进一步探讨。
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