Chen H D, Fraire A E, Joris I, Brehm M A, Welsh R M, Selin L K
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Nat Immunol. 2001 Nov;2(11):1067-76. doi: 10.1038/ni727.
A potent role for memory CD8+ T cells in heterologous immunity was shown with a respiratory mucosal model of viral infection. Memory CD8+ T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.
在病毒感染的呼吸道黏膜模型中，记忆性CD8 + T细胞在异源免疫中发挥了重要作用。淋巴细胞性脉络丛脑膜炎病毒（LCMV）感染后产生的记忆性CD8 + T细胞，在痘苗病毒（VV）急性感染期间于体内被功能性激活，产生γ干扰素（IFN-γ）。其中一些抗原特异性记忆细胞数量选择性增加，导致原始LCMV特异性T细胞库发生改变。此外，在VV感染期间，这些LCMV特异性T细胞存在器官选择性的区室重新分布。这些LCMV特异性记忆T细胞的存在与VV清除增强、死亡率降低以及肺部免疫病理学的显著变化相关。因此，针对不相关病原体的预先存在的记忆T细胞的参与，可以改变黏膜免疫的动力学和对病原体的疾病进程。
