Duggal M S, Toumba K J, Amaechi B T, Kowash M B, Higham S M
Division of Child Dental Health, Leeds Dental Institute, UK.
J Dent Res. 2001 Aug;80(8):1721-4. doi: 10.1177/00220345010800080801.
There is little information in the literature on the relationship among the frequency of carbohydrate consumption, the use of fluoride toothpaste, and enamel demineralization. The aim of this investigation was to compare the extent of demineralization of enamel slabs in situ, with a sugar-based solution, consumed in constant amounts but with various frequencies in subjects both with and without the use of fluoride (F) toothpaste. Eight subjects wore removable mandibular appliances carrying an enamel slab cut from white-spot lesions. The subjects were required to drink 500 mL of a 120-gm/L sugar solution either once, 3, 5, 7, or 10 times/day for 30 sec on each occasion, for a period of 5 days while brushing their teeth twice daily with either a F (1450 ppm NaF) or a F-free toothpaste. Mineral analysis revealed that when the subjects used a F toothpaste, net demineralization was evident only with the seven- and 10-times/day regime (ns). When F-free toothpaste was used, statistically significant demineralization was observed when the frequency exceeded 3 times/day. This study demonstrates the importance of F-containing toothpaste in enamel re-/demineralization by varying the frequency of carbohydrate challenge
关于碳水化合物摄入频率、含氟牙膏使用情况与牙釉质脱矿之间的关系，文献中几乎没有相关信息。本研究的目的是比较在使用和不使用含氟（F）牙膏的受试者中，原位牙釉质块在以恒定剂量但不同频率摄入含糖溶液时的脱矿程度。八名受试者佩戴可摘式下颌矫治器，矫治器上带有从白斑病变处切下的牙釉质块。受试者被要求每天饮用500毫升120克/升的糖溶液，每次饮用30秒，饮用频率分别为每天1次、3次、5次、7次或10次，持续5天，同时每天用含F（1450 ppm氟化钠）牙膏或不含F牙膏刷牙两次。矿物质分析表明，当受试者使用含F牙膏时，仅在每天7次和10次的摄入频率下有明显的净脱矿现象（无统计学意义）。当使用不含F牙膏时，摄入频率超过每天3次时观察到有统计学意义的脱矿现象。本研究表明，含F牙膏通过改变碳水化合物刺激的频率，在牙釉质再矿化/脱矿过程中具有重要作用
