Xiang P, Shen M, Bu J, Huang Z
Department of Forensic Chemistry, Institute of Forensic Science, Ministry of Justice, Guangfu Xi Road 1347, Shanghai 200063, PR China.
Forensic Sci Int. 2001 Nov 1;122(2-3):159-62. doi: 10.1016/s0379-0738(01)00491-1.
The stability of tetramine, morphine and meperidine in formalin solution is an important factor for drug analysis in forensic investigation. In this paper, the tissues (liver, kidney, lung and heart) from poisoned rabbits were immersed in 50 ml 10% formalin solutions for 4 months before examination. We compared the levels of tetramine, morphine, meperidine and the main metabolite normeperidine, measured by GC/NPD or GC-MS, in frozen rabbit tissues, formalin-fixed rabbit tissues, and formalin solution. There was a decrease in the levels of tetramine, morphine, meperidine in formalin-preserved tissues compared with the levels of these drugs in the frozen tissues. It is suggested that the formalin-fixed tissues and formalin solution should be analyzed at the same time to assure the accurate results.
毒鼠强、吗啡和哌替啶在福尔马林溶液中的稳定性是法医调查中药物分析的一个重要因素。本文中，将中毒家兔的组织（肝脏、肾脏、肺和心脏）在检查前于50毫升10%福尔马林溶液中浸泡4个月。我们比较了通过气相色谱/氮磷检测器（GC/NPD）或气相色谱-质谱联用仪（GC-MS）测定的，在冷冻家兔组织、福尔马林固定家兔组织以及福尔马林溶液中毒鼠强、吗啡、哌替啶及其主要代谢产物去甲哌替啶的含量。与冷冻组织中这些药物的含量相比，福尔马林保存组织中毒鼠强、吗啡、哌替啶的含量有所降低。建议同时对福尔马林固定组织和福尔马林溶液进行分析，以确保结果准确。
