Su-Gwan K, Hak-Kyun K, Sung-Chul L
Department of Oral and Maxillofacial Surgery, Oral Biology Research Institute, Chosun University, Kwang-Ju, Korea.
J Craniomaxillofac Surg. 2001 Oct;29(5):282-8. doi: 10.1054/jcms.2001.0236.
The purpose of this study is to assess the combination of particulate dentine and plaster as bone substitute material in calvarial bone defects in rats, and to compare it with a bone xenograft (Bio-Oss).
Forty rats were assigned randomly to five groups and each group was further divided into two subgroups, 8 and 16 weeks after implantation. The defect was filled with different graft materials in each group: Group 1, defects were filled with particulate dentine and plaster using a 2:1 ratio; Group 2, defects were filled with particulate dentine; plaster, and Bio-Oss using a 2:1:1 ratio; Group 3, defects were filled with plaster and Bio-Oss using a 1:1 ratio; Group 4, defects were filled with Bio-Oss only; and Group 5, untreated control defects. Histological sections and histomorphometric analysis of defects were obtained at 8 and 16 weeks postoperatively.
New bone formation was highest in Group 4, followed by Group 3, than Group 2, Group 1, and finally the control group.
The combination of particulate dentine and plaster is an alternative bone substitute, although it is less effective than Bio-Oss.
本研究的目的是评估颗粒状牙本质和石膏作为大鼠颅骨骨缺损骨替代材料的组合，并将其与骨异种移植物（Bio-Oss）进行比较。
40只大鼠随机分为五组，每组在植入后8周和16周进一步分为两个亚组。每组用不同的移植材料填充缺损：第1组，缺损用颗粒状牙本质和石膏按2:1的比例填充；第2组，缺损用颗粒状牙本质、石膏和Bio-Oss按2:1:1的比例填充；第3组，缺损用石膏和Bio-Oss按1:1的比例填充；第4组，缺损仅用Bio-Oss填充；第5组，为未处理的对照缺损。术后8周和16周获取缺损的组织学切片和组织形态计量分析。
第4组新骨形成最高，其次是第3组，然后是第2组、第1组，最后是对照组。
颗粒状牙本质和石膏的组合是一种替代骨替代物，尽管其效果不如Bio-Oss。
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