Seto F
J Exp Zool. 1975 Feb;191(2):287-93. doi: 10.1002/jez.1401910214.
An experimental model for the analysis of antibody-mediated regulation of specific immune responsiveness in chickens is described. Chick embryos and day-old chicks were passively administered homologous serum with high anti-mouse erythrocyte (MRBC) activity and then tested for immune responsiveness to MRBC several weeks later. Compared to the untreated controls, the hemagglutinin titers of experimental birds were obviously depressed for 2 to 3 weeks but near normal by the 4th week. The inhibitory property of homologous serum appeared directly related to the anit-MRBC activity; serum samples collected on day 1 and 2 after immunization were ineffective and low in specific activity, whereas those collected after the 3rd day were progressively more inhibitory as the anti-MRBC activity increased.
本文描述了一种用于分析鸡体内抗体介导的特异性免疫反应调节的实验模型。给鸡胚胎和一日龄雏鸡被动注射具有高抗小鼠红细胞（MRBC）活性的同源血清，然后在数周后检测它们对MRBC的免疫反应性。与未处理的对照组相比，实验鸡的血凝素滴度在2至3周内明显降低，但在第4周时接近正常水平。同源血清的抑制特性似乎与抗MRBC活性直接相关；免疫后第1天和第2天收集的血清样本无抑制作用且特异性活性低，而第3天后收集的血清样本随着抗MRBC活性的增加抑制作用逐渐增强。
