Seto F
Dev Comp Immunol. 1977 Apr;1(2):145-56. doi: 10.1016/s0145-305x(77)80007-4.
The immunologic immaturity of embryos and newly hatched chicks to MRBC immunization has provided us with a model to investigate the distribution of immunocytes and their precursors in several tissues of juvenile chickens. Antigen-responsive cells (ARC) were rare in the peripheral blood, spleen, bone marrow, thymus and bursa of Fabricius of unimmunized young birds. Following MRBC immunization, they were abundant in the blood and spleen, low in frequency in bone marrow and absent in the thymus and bursa. The recipients of bone marrow cells, thymocytes, or bursacytes, when immunized at hatching, exhibited accelerated humoral immune responses. The enhancement property of the grafted cells was increased when MRBC was included in the cell suspension at the time of grafting. The precocious responsiveness of the grafted chicks is attributed to the cooperation of donor and host immunocytes. The enhancement effect, moreover, was less consistently expressed in allogeneic hosts. This capacity was aquired by thymic cells within a day after immunization of the donor and persisted well over a week. The role of antigen in driving the specific differentiation of T and Bu cells is briefly discussed.
胚胎和刚孵出的雏鸡对红细胞免疫的免疫不成熟为我们提供了一个模型，用于研究幼年鸡几种组织中免疫细胞及其前体的分布。在未免疫的幼鸟的外周血、脾脏、骨髓、胸腺和法氏囊中，抗原反应细胞（ARC）很少见。用红细胞免疫后，它们在血液和脾脏中大量存在，在骨髓中的频率较低，在胸腺和法氏囊中不存在。骨髓细胞、胸腺细胞或法氏囊细胞的受体在孵化时免疫，表现出加速的体液免疫反应。当在移植时将红细胞包含在细胞悬液中时，移植细胞的增强特性会增加。移植雏鸡的早熟反应性归因于供体和宿主免疫细胞的合作。此外，在同种异体宿主中，增强效应的表达不太一致。这种能力在供体免疫后一天内由胸腺细胞获得，并持续超过一周。本文简要讨论了抗原在驱动T细胞和B细胞特异性分化中的作用。
