Perlo V P, Arnason B, Castleman B
Neurology. 1975 Mar;25(3):294-5. doi: 10.1212/wnl.25.3.294.
This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On microscopic examination, 11 patients had no thymic tissue. The other nine patients, including the one with thymectomy, all showed marked involution of the thymus. No germinal centers were seen. The thymus glands of two additional patients, still alive after thymectomy at ages 62 and 70, showed similar findings. Marked involution of the thymus also was found in each of six elderly controls. Thymectomy is not likely to be effective treatment of the elderly myasthenic patient.
本研究旨在确定20例60岁以上重症肌无力患者死后切除的残留胸腺组织的数量和组织学表现。1例患者在胸腺切除术后数天死亡。所有患者大体检查均未见可识别的胸腺组织。显微镜检查显示，11例患者无胸腺组织。其他9例患者，包括接受胸腺切除术的1例，均显示胸腺明显萎缩。未见生发中心。另外2例分别于62岁和70岁行胸腺切除术后仍存活的患者的胸腺也有类似表现。6例老年对照者的胸腺也均有明显萎缩。胸腺切除术对老年重症肌无力患者可能无效。
