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通过免疫球蛋白受体和丝裂原反应性鉴定的人类T细胞亚群。

Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness.

作者信息

Moretta L, Ferrarini M, Mingari M C, Moretta A, Webb S R

出版信息

J Immunol. 1976 Dec;117(6):2171-4.

PMID:792341
Abstract

Human T lymphocytes in peripheral blood have been shown to have receptors for IgG (Tgamma) or IgM (Tmu). Cultured Tgamma cells do not express receptors for IgM and purified Tmu cells do not have receptors for IgG, thus they appear to be distinct T cell populations. Although the two subpopulations show similar response patterns to concanavalin A, Tmu and Tgamma cells exhibit different dose-response curves to phytohemagglutinin. The normal response pattern to phytohemagglutinin requires a mixture of T cell subpopulations suggesting that synergistic interactions may occur.

摘要

外周血中的人类T淋巴细胞已被证明具有IgG(Tγ)或IgM(Tμ)受体。培养的Tγ细胞不表达IgM受体,纯化的Tμ细胞也没有IgG受体,因此它们似乎是不同的T细胞群体。尽管这两个亚群对刀豆球蛋白A表现出相似的反应模式,但Tμ和Tγ细胞对植物血凝素表现出不同的剂量反应曲线。对植物血凝素的正常反应模式需要T细胞亚群的混合,这表明可能发生协同相互作用。

相似文献

1
Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness.通过免疫球蛋白受体和丝裂原反应性鉴定的人类T细胞亚群。
J Immunol. 1976 Dec;117(6):2171-4.
2
Separation of human T lymphocyte subpopulations (Tmu, Tgamma) by density gradient electrophoresis.通过密度梯度电泳分离人T淋巴细胞亚群(Tmu、Tgamma)。
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1972-6. doi: 10.1073/pnas.76.4.1972.
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Subpopulations of human T lymphocytes. X. Alterations in T, B, third population cells, and T cells with receptors for immunoglobulin M (Tmu) or G (Tgamma) in aging humans.人类T淋巴细胞亚群。X. 衰老人类中T细胞、B细胞、第三群细胞以及具有免疫球蛋白M(Tμ)或G(Tγ)受体的T细胞的变化。
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Subpopulations of human T lymphocytes. I. Studies in immunodeficient patients.人类T淋巴细胞亚群。I. 对免疫缺陷患者的研究。
Clin Exp Immunol. 1977 Nov;30(2):222-8.
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Immunologic functions of isolated human lymphocyte subpopulations. I. Quantitative isolation of human T and B cells and response to mitogens.分离的人淋巴细胞亚群的免疫功能。I. 人T细胞和B细胞的定量分离及对有丝分裂原的反应。
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Human bone marrow lymphocytes. I. Distribution of lymphocyte subpopulations in the bone marrow of normal individuals.人骨髓淋巴细胞。I. 正常个体骨髓中淋巴细胞亚群的分布。
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Lymphocyte receptors. II. Receptors for rabbit IgM on human T lymphocytes.淋巴细胞受体。II. 人T淋巴细胞上兔IgM的受体
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[Immunological activities of rat lymphocytes. III. --Isolation of differing subpopulations of lymphocytes by two techniques of T cell separation].[大鼠淋巴细胞的免疫活性。III. —— 通过两种T细胞分离技术分离不同淋巴细胞亚群]
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J Immunol. 1979 May;122(5):1855-62.

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人外周血淋巴细胞上IgM受体的体外培养特性及表达要求。
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Selective inhibition of thromboxane biosynthesis in human blood mononuclear cells and the effects of mitogen-stimulated lymphocyte proliferation.人血单核细胞中血栓素生物合成的选择性抑制及丝裂原刺激的淋巴细胞增殖的影响
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Comparison of the inhibition by glucocorticosteroids and cyclosporin A of mitogen-stimulated human lymphocyte proliferation.糖皮质激素和环孢素A对丝裂原刺激的人淋巴细胞增殖抑制作用的比较。
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