人类IgM的T细胞受体：对五聚体Fc片段的特异性。
Human T cell receptor for IgM: specificity for the pentameric Fc fragment.
作者信息
Ferrarini M, Moretta L, Mingari M C, Tonda P, Pernis B
出版信息
Eur J Immunol. 1976 Jul;6(7):520-1. doi: 10.1002/eji.1830060714.
The specificity of the IgM receptor expressed by human T cells cultured in IgM-free media has been investigated. IgM receptors have been detected using a rosette system with ox erythrocytes coated with rabbit antibody (EA(IgM)), and the inhibitory capacity of different IgM fragments in the rosette system has been tested. It was found that F(c)5mu but not F(ab')2mu, nor monomeric IgM (8 S IgM) inhibited EA (IgM) rosette-forming cells. This indicates that the receptor present on the surface of T cells has affinity for a structure located in the Fc portion of the pentameric IgM.
已对在无IgM培养基中培养的人T细胞所表达的IgM受体的特异性进行了研究。使用与包被有兔抗体的牛红细胞（EA(IgM)）的玫瑰花结系统检测IgM受体，并测试了玫瑰花结系统中不同IgM片段的抑制能力。发现F(c)5μ而非F(ab')2μ，也不是单体IgM（8S IgM）抑制EA（IgM）玫瑰花结形成细胞。这表明T细胞表面存在的受体对位于五聚体IgM Fc部分的结构具有亲和力。
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