马卡鲁瓦明P，一种从类似煤烟色泽漆中分离出的新型细胞毒性吡咯并亚氨基醌。

Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa.

作者信息

Casapullo A, Cutignano A, Bruno I, Bifulco G, Debitus C, Gomez-Paloma L, Riccio R

机构信息

Dipartimento di Scienze Farmaceutiche, Università di Salerno, 84084 Fisciano (SA), Italy.

出版信息

J Nat Prod. 2001 Oct;64(10):1354-6. doi: 10.1021/np010053+.

DOI:10.1021/np010053+

PMID:11678667

Abstract

A new pyrroloiminoquinone alkaloid (1) belonging to the makaluvamine family has been isolated from the sponge Zyzzya cf. fuliginosa collected in the waters off the Vanuatu Islands. The compound, designated makulavamine P, was characterized on the basis of its spectral data and displayed cytoxicity in the microM range on KB cells and antioxidant activity.

摘要

从瓦努阿图群岛海域采集的类似烟黑海绵（Zyzzya cf. fuliginosa）中分离出一种属于马卡鲁胺家族的新型吡咯并亚氨基醌生物碱（1）。该化合物被命名为马卡鲁胺P，通过光谱数据对其进行了表征，并在 microM 范围内对 KB 细胞显示出细胞毒性和抗氧化活性。