3,7 - 二甲基鸟嘌呤，一种从菲律宾海绵Zyzzya fuliginosa中提取的新型嘌呤。

3,7-Dimethylguanine, a new purine from a Philippine sponge Zyzzya fuliginosa.

作者信息

Tasdemir D, Mangalindan G C, Concepción G P, Harper M K, Ireland C M

机构信息

Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112, USA.

出版信息

Chem Pharm Bull (Tokyo). 2001 Dec;49(12):1628-30. doi: 10.1248/cpb.49.1628.

DOI:10.1248/cpb.49.1628

PMID:11767085

Abstract

A new purine 3,7-dimethylguanine (1) has been isolated from the marine sponge Zyzzya fuliginosa, along with the known metabolites, makaluvamines A, C, K (2--4), 4-hydroxyphenylacetic acid (5), methyl ester of 4-hydroxyphenylacetic acid (6), 4-hydroxyphenethyl alcohol (7), L-phenylalanine (8) and L-tryptophan (9). The structure of 3,7-dimethylguanine (1) was elucidated by analysis of 1D and 2D (one- and two-dimensional) NMR [HMQC (heteronuclear multiple quantum coherence), gHMBC (heteronuclear multiple bond connectivity), 1H-15N gHMBC] data, mass spectroscopy data, and by comparison with 3,7-dimethylisoguanine (10).

摘要

从海洋海绵Zyzzya fuliginosa中分离出一种新的嘌呤3,7-二甲基鸟嘌呤（1），同时还分离出了已知的代谢产物马卡鲁胺A、C、K（2 - 4）、4-羟基苯乙酸（5）、4-羟基苯乙酸甲酯（6）、4-羟基苯乙醇（7）、L-苯丙氨酸（8）和L-色氨酸（9）。通过对一维和二维（1D和2D）核磁共振[HMQC（异核多量子相干）、gHMBC（异核多键连接）、1H-15N gHMBC]数据、质谱数据的分析，并与3,7-二甲基异鸟嘌呤（10）进行比较，阐明了3,7-二甲基鸟嘌呤（1）的结构。